Results 11 to 20 of about 3,067,072 (318)
JAK inhibitors: A new dawn for oral therapies in inflammatory bowel diseases [PDF]
Frontiers in Medicine, 2023 Inflammatory bowel disease (IBD) is a chronic immune-mediated condition of the gastrointestinal tract that requires chronic treatment and strict surveillance.
Claudia Herrera-deGuise +3 more
doaj +3 more sources
Adverse events in patients treated with Jak-inhibitors for alopecia areata: a systematic review. [PDF]
Journal of the European Academy of Dermatology and Venereology, 2023 Recently, the impressive efficacy of JAK-inhibitors (JAK-I) in alopecia areata (AA) has been described in several studies; however, to date, there is limited information on the safety of JAK-I in AA patients.
Piraccini, B M +13 more
core +2 more sources
JID Innovations, 2023 Recently, Jak inhibitors such as baricitinib, upadacitinib, and abrocitinib were approved for the treatment of atopic dermatitis (AD) in addition to biologics, including dupilumab, tralokinumab, and nemolizumab. The increase in treatment options can be a
Masahiro Kamata, Yayoi Tada
doaj +2 more sources
A Comprehensive Overview of Globally Approved JAK Inhibitors
Pharmaceutics, 2022 Janus kinase (JAK) is a family of cytoplasmic non-receptor tyrosine kinases that includes four members, namely JAK1, JAK2, JAK3, and TYK2. The JAKs transduce cytokine signaling through the JAK-STAT pathway, which regulates the transcription of several ...
Ashraf N. Abdalla +9 more
core +2 more sources
Journal of Allergy and Clinical Immunology, 2021 Asthma is an inflammatory disease of the airways characterized by intermittent episodes of wheezing, chest tightness, and cough. Many of the inflammatory pathways implicated in asthma involve cytokines and growth factors that activate Janus kinases (JAKs).
Steve N, Georas +3 more
openaire +4 more sources
JAK inhibitors and autoimmune rheumatic diseases
Autoimmunity Reviews, 2023 The four Janus kinase (JAK) proteins and the seven Signal Transducers of Activated Transcription (STAT) mediate intracellular signal transduction downstream of cytokine receptors, which are involved in the pathology of allergic, autoimmune, and inflammatory diseases.
Benucci M +14 more
openaire +5 more sources
Scope of JAK Inhibitors in Children:Recent Evidence and Way Forward
Pediatric Drugs, 2023 Over the last decade, there has been an increase in the use of targeted therapy using small molecules such as Janus kinase (JAK) inhibitors. Since the introduction of ruxolitinib, the first non-selective JAK inhibitor approved for use in myelofibrosis ...
Ramanan, A. V. +2 more
core +2 more sources
Recent developments for new investigational JAK inhibitors in psoriatic arthritis
Expert Opinion on Investigational Drugs, 2023 IntroductionPsoriatic arthritis (PsA) is a chronic inflammatory disease affecting about one-third of subjects with psoriasis. several treatment modalities targeting Janus Kinase pathways and intracellular inflammatory cascade are now available and under ...
Francesco Caso +15 more
core +3 more sources
JAK-STAT pathway inhibitors in dermatology
Anais Brasileiros de Dermatologia, 2023 The JAK-STAT signaling pathway mediates important cellular processes such as immune response, carcinogenesis, cell differentiation, division and death. Therefore, drugs that interfere with different JAK-STAT signaling patterns have potential indications for various medical conditions.
Hélio Amante Miot +5 more
openaire +5 more sources
JAK Inhibitors and Oxidative Stress Control [PDF]
Frontiers in Immunology, 2019 Primary Sjögren's syndrome (SjS) is a complex autoimmune epithelitis, with few treatment options, but the use of Janus kinase (JAK) inhibitors is promising because suppression of the JAK/signal transducer and activator of transcription (STAT) pathway improves sicca manifestations.
Amandine Charras +11 more
openaire +5 more sources