Results 31 to 40 of about 126,141 (353)

A multitask GNN-based interpretable model for discovery of selective JAK inhibitors

Journal of Cheminformatics, 2022
The Janus kinase (JAK) family plays a pivotal role in most cytokine-mediated inflammatory and autoimmune responses via JAK/STAT signaling, and administration of JAK inhibitors is a promising therapeutic strategy for several diseases including COVID-19 ...
Yimeng Wang, Yaxin Gu, Chaofeng Lou, Yuning Gong, Zengrui Wu, Weihua Li, Yun Tang, Guixia Liu   +7 more
doaj   +1 more source

JAK Inhibitors — More Than Just Glucocorticoids

New England Journal of Medicine, 2021
Most persons who are infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are asymptomatic or have only mild-to-moderate symptoms, whereas others have progression to severe di...
Justin Stebbing, Volker M. Lauschke
openaire   +4 more sources

Janus-kinase Inhibitors in Pathogenesis and Management of Chronic Urticaria: A Review of the Literature [PDF]

Journal of Pediatrics Review, 2023
Background: Chronic urticaria is a long-lasting condition, sometimes with serious comorbidities, severely affecting the quality of life, which makes the patients seek efficient therapies to achieve sustained remissions.
Sepideh Darougar, Seyed Karen Hashemitari, Sara Montazeri Namin   +2 more
doaj  

CRLF2 rearrangement in Ph-like acute lymphoblastic leukemia predicts relative glucocorticoid resistance that is overcome with MEK or Akt inhibition. [PDF]

, 2019
Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukemia (ALL) is a genetically heterogeneous subtype of B-cell ALL characterized by chromosomal rearrangements and mutations that result in aberrant cytokine receptor and kinase signaling.
Delgado-Martin, Cristina, Hermiston, Michelle L, Maude, Shannon L, Meyer, Lauren K, Shannon, Kevin M, Teachey, David T   +5 more
core   +2 more sources

JAK-STAT pathway inhibitors in dermatology

Anais Brasileiros de Dermatologia, 2023
The JAK-STAT signaling pathway mediates important cellular processes such as immune response, carcinogenesis, cell differentiation, division and death. Therefore, drugs that interfere with different JAK-STAT signaling patterns have potential indications for various medical conditions.
Hélio Amante Miot, Paulo Ricardo Criado, Caio César Silva de Castro, Mayra Ianhez, Carolina Talhari, Paulo Müller Ramos   +5 more
openaire   +4 more sources

Rheumatoid arthritis [PDF]

, 2016
Rheumatoid arthritis is a chronic inflammatory joint disease, which can cause cartilage and bone damage as well as disability. Early diagnosis is key to optimal therapeutic success, particularly in patients with well-characterised risk factors for poor ...
Aletaha, Daniel, McInnes, Iain B., Smolen, Josef S.   +2 more
core   +1 more source

Janus kinase inhibitors for the treatment of rheumatoid arthritis demonstrate similar profiles of in vitro cytokine receptor inhibition

Pharmacology Research & Perspectives, 2019
Janus kinase (JAK) inhibitors have emerged as an effective class of therapies for various inflammatory diseases such as rheumatoid arthritis (RA). JAK inhibitors function intracellularly by modulating the catalytic activity of JAKs and disrupting the ...
Martin E. Dowty, Tsung H. Lin, Michael I. Jesson, Martin Hegen, David A. Martin, Vaibhav Katkade, Sujatha Menon, Jean‐Baptiste Telliez   +7 more
doaj   +1 more source

Risk of venous thromboembolism with janus kinase inhibitors in inflammatory immune diseases: a systematic review and meta-analysis

Frontiers in Pharmacology, 2023
Objectives: This study aimed to evaluate the risk of venous thrombosis (VTE) associated with Janus kinase (JAK) inhibitors in patients diagnosed with immune-mediated inflammatory diseases.Methods: We conducted a comprehensive search of PUBMED, Cochrane ...
Juqi Zhang, Juqi Zhang, Juqi Zhang, Wenhui Li, Wenhui Li, Wenhui Li, Mingli Gong, Yanlun Gu, Yanlun Gu, Yanlun Gu, Hanxu Zhang, Hanxu Zhang, Hanxu Zhang, Bingqi Dong, Qi Guo, Qi Guo, Qi Guo, Xiaocong Pang, Xiaocong Pang, Qian Xiang, Qian Xiang, Xu He, Xu He, Yimin Cui, Yimin Cui, Yimin Cui   +25 more
doaj   +1 more source

Structure, function and inhibition of poly(ADP-ribose)polymerase, member 14 (PARP14) [PDF]

, 2018
Poly(ADP-ribose)polymerase, member 14 (PARP14, alternatively named ARTD8, BAL2, and COAST6) is an intracellular mono(ADP-ribosyl) transferase. PARP14 transfers a negatively charged ADP-ribose unit from a donor NAD+ molecule onto a target protein, post ...
Levonis, Stephan M, Schweiker, Stephanie S, Sherry, Madeleine, Tauber, Amanda   +3 more
core   +1 more source

Targeting the Janus Kinase Family in Autoimmune Skin Diseases

Frontiers in Immunology, 2019
Autoimmune skin diseases are characterized by significant local and systemic inflammation that is largely mediated by the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway.
Michael D. Howell, Fiona I. Kuo, Paul A. Smith   +2 more
doaj   +1 more source