Results 271 to 280 of about 126,141 (353)

Vaccination Recommendations in Patients With Atopic Dermatitis Treated With JAK Inhibitors. [PDF]

Int J Dermatol
Ara-Martín M, Moreno C, Ruiz-Villaverde R, Serra-Baldrich E, Hernández-Martín I, Del Pilar Fortes M.   +5 more
europepmc   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Strategies for Managing Suboptimal Response to JAK Inhibitors in Alopecia Areata. [PDF]

Acta Derm Venereol
Seyed Jafari SM, De Viragh PA.
europepmc   +1 more source

Multifaceted Intervention by the Hsp90 Inhibitor Ganetespib (STA-9090) in Cancer Cells with Activated JAK/STAT Signaling

, 2011
David A. Proia, Kevin P. Foley, Tim Korbut, Jim Sang, Don Smith, Richard C. Bates, Yuan Liu, Alex Rosenberg, Dan Zhou, Keizo Koya, James Barsoum, Ronald K. Blackman   +11 more
openalex   +2 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

JAK Inhibitors for Treatment of SAPHO Syndrome: A Systematic Review of 72 Cases. [PDF]

ACR Open Rheumatol
Fazeli P, Bahramian S, Farahmand K, Ghoshouni H, Farahmand Y, Soheili A, Bagheri L, Memari H, Feyzi A, Vahabi SM.   +9 more
europepmc   +1 more source

3-Amido Pyrrolopyrazine JAK Kinase Inhibitors: Development of a JAK3 vs JAK1 Selective Inhibitor and Evaluation in Cellular and in Vivo Models

, 2012
Michael Soth, Johannes C. Hermann, Calvin Yee, Muzaffar Alam, Jim Barnett, Pamela Berry, Michelle F. Browner, Karl Frank, Sandra Frauchiger, Seth F. Harris, Yang He, Mohammad Hekmat-Nejad, Than Hendricks, Robert Henningsen, Ramona Hilgenkamp, Hoangdung Ho, Ann F. Hoffman, Pei-Yuan Hsu, Dong‐Qing Hu, Andrea Itano, Saul Jaime‐Figueroa, Alam Jahangir, Sue Jin, A. Kuglstatter, Alan K. Kutach, Cheng Liao, Stephen M. Lynch, John G. Menke, Linghao Niu, Vaishali Patel, Aruna Railkar, Douglas Roy, A. Shao, David E. Shaw, Sandra Steiner, Yongliang Sun, Seng‐Lai Tan, Sandra Wang, Minh Diem Vu   +38 more
openalex   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Clinical and Ultrasound Remission in Rheumatoid Arthritis Patients Treated with JAK Inhibitors: A Real-World Study. [PDF]

J Clin Med
Lasa-Teja C, Fernández-Cabero JJ, Sánchez-Bilbao L, Loricera J, González-Mazón I, Álvarez-Reguera C, Herrero-Morant A, Corrales-Martínez A, Portilla-González V, Martín-Varillas JL, Pérez-Garrido L, Santos-Gómez M, López-Hoyos M, Blanco R.   +13 more
europepmc   +1 more source