Results 91 to 100 of about 1,078,243 (279)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Order parameter model for unstable multilane traffic flow

, 2000
We discuss a phenomenological approach to the description of unstable vehicle motion on multilane highways that explains in a simple way the observed sequence of the phase transitions "free flow -> synchronized motion -> jam" as well as the hysteresis in
A. Zerr, A.M. Liu, A.Y. Liu, A.Y. Liu, F. Birch, G. Serghiou, H.J. Monkhorst, I. Chambouleyron, J. E. Lowther, J.E. Lowther, M. Bockstede, N. Troullier, P. Kroll, R. Juza, S. Mo, S.N. Ruddlesden, W.C. Johnson, Y.K. Chang   +17 more
core   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Improving the Hydraulic and Chemical Properties of Sandy Soil by Using a Mixture of Biochar and Clay

iRASD Journal of Energy & Environment
In recent years, food demand has risen due to rapid population surge. Meeting this food demand means more land is supposed to be cultivated. Yet, there are many areas in Sindh, Pakistan, particularly “Thar,” where crop yield is inadequate due to the ...
Lareb Bhirai, Mahmood Laghari, Hafeez-Ur- Rehman, Rajesh Kumar   +3 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Corrigendum

Jurnal Aplikasi Manajemen
Corrigendum to “The Role of Women Merchants in Increasing Family’s Income (A Case Study on Indigenous Papuan Women Merchants)“ [JAM: Jurnal Aplikasi Manajemen, 14(4), 641-649]
JAM JAM
doaj   +1 more source

Evaluation of Yield and Some Root and Morphological Characteristics Response of Guar (Cyamopsis tetragonoloba L.) in Intercropping with Roselle (Hibiscus sabdariffa L.) under Nitrogen Fertilizer Management [PDF]

بوم شناسی کشاورزی
IntroductionGuar (Cyamopsis tetragonoloba L.)  is an annual plant that tolerates salinity and drought from the legume family, which can be used as an alternative product in low-water plains. Considering the characteristics of the guar, such as having the
Mohammadnaser Modoodi, Vahid Shamsabadi, Ebrahim Jahangir Dehborzoui   +2 more
doaj   +1 more source

Absolute bacterial cell enumeration using flow cytometry

, 2017
Aim: To evaluate a flow cytometry protocol that uses reference beads for the enumeration of live and dead bacteria present in a mixture. Methods and Results: Mixtures of live and dead Escherichia coli with live:dead concentration ratios varying from 0 to
McGoverin, Cushla, Ou, Fang, Swift, Simon, Vanholsbeeck, Frederique   +3 more
core   +1 more source