Results 11 to 20 of about 80,577 (303)
Janus kinase inhibitors: jackpot or potluck? [PDF]
Oncology Reviews, 2012 The reports of a unique mutation in the Janus kinase-2 gene (JAK2) in polycythemia vera by several independent groups in 2005 quickly spurred the development of the Janus kinase inhibitors.
Pavithran Keechilat +1 more
doaj +2 more sources
Janus Kinase Deregulation in Leukemia and Lymphoma [PDF]
Immunity, 2012 Genetic alterations affecting members of the Janus kinase (JAK) family have been discovered in a wide array of cancers and are particularly prominent in hematological malignancies. In this review, we focus on the role of such lesions in both myeloid and lymphoid tumors.
Chen, Edwin +2 more
openaire +4 more sources
Janus kinase inhibitors: between prescription authorization and reimbursability [PDF]
Reumatismo, 2023 Following the restrictions on the reimbursability of Janus kinase inhibitors introduced by the Italian Medicines Agency, the Italian Society of Rheumatology has drafted this document to shed light on the clinical conditions and reimbursability criteria ...
F.R. Spinelli +5 more
doaj +6 more sources
Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression [PDF]
Cell Reports, 2018 Summary: Janus kinases (JAKs) and their downstream STAT proteins play key roles in cytokine signaling, tissue homeostasis, and cancer development. Using a breast cancer model that conditionally lacks Janus kinase 1, we show here that JAK1 is essential ...
Barbara L. Wehde +5 more
doaj +2 more sources
Janus Kinase Inhibitors: Safety in Patients With Psoriatic Arthritis [PDF]
, 2022 Janus kinase inhibitors (JAKi; or Jakinibs) have become widely prescribed around the world for a variety of immune-mediated inflammatory diseases, including psoriatic arthritis.
Nash, P
core +1 more source
A comparison of Janus kinase inhibitor safety in rheumatoid arthritis [PDF]
, 2021 The last decade has seen considerable advancement in the treatment options available to patients with rheumatoid arthritis (RA) through the development of oral, small molecules that target and inhibit Janus kinases (JAKi).
Marabani, Mona +5 more
core +1 more source
A literature review of the Janus kinase inhibitors used in the treatment of auto-immune dermatological conditions [PDF]
, 2022 © 2022 The Authors. Published by Archives of Pharmacy Practice. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.51847 ...
Morrissey, Hana +3 more
core +1 more source
Therapeutic targeting of Janus kinases [PDF]
Immunological Reviews, 2008 SummaryCytokines play pivotal roles in immunity and inflammation, and targeting cytokines and their receptors is an effective means of treating such disorders. Type I and II cytokine receptors associate with Janus family kinases (JAKs) to effect intracellular signaling.
Marko, Pesu +5 more
openaire +2 more sources
Journal of the Scientific Society, 2023 Background: Coronavirus disease 2019 (COVID-19), it is an infectious respiratory disease caused by SARS corona virus 2 (SARS CoV-2). There are several reports of using JAK (Janus kinase)-inhibitors in persons with COVID-19 and the use of these decreased ...
Shankar Gharge +3 more
doaj +1 more source
Janus Kinase Inhibitors in the Treatment of Alopecia Areata
Prague Medical Report, 2023 Alopecia areata is a disease of autoimmune origin which causes non scarring hair loss. The extent of alopecia varies from a small patch to complete scalp and body hair loss, which can have huge psychosocial impact for those affected. Treatment modalities
Athanasios J. Stefanis
doaj +1 more source