Results 141 to 150 of about 107,749 (252)

Cytotoxicity of various types of gold-mesoporous silica nanoparticles in human breast cancer cells

International Journal of Nanomedicine, 2015
Guomu Liu,1,* Qiongshu Li,1,2,* Weihua Ni,1 Nannan Zhang,1 Xiao Zheng,3 Yingshuai Wang,4 Dan Shao,3 Guixiang Tai1 1Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, 2Shenzhen Beike Cell Engineering Research ...
Liu G, Li Q, Ni W, Zhang N, Zheng X, Wang Y, Shao D, Tai G   +7 more
doaj  

miR-20a-5p inhibits endometrial cancer progression by targeting janus kinase 1. [PDF]

Oncol Lett, 2021
He Y, Ma H, Wang J, Kang Y, Xue Q.
europepmc   +1 more source

Structure, function and inhibition of poly(ADP-ribose)polymerase, member 14 (PARP14) [PDF]

, 2018
Levonis, Stephan M, Schweiker, Stephanie S, Sherry, Madeleine, Tauber, Amanda   +3 more
core   +1 more source

Novel Therapeutics for Chronic Obstructive Pulmonary Disease: From Empirical Bronchodilation to Precision Medicine

Respirology, EarlyView.
ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley   +1 more source

Selectivity Profile of the Tyrosine Kinase 2 Inhibitor Deucravacitinib Compared with Janus Kinase 1/2/3 Inhibitors. [PDF]

Dermatol Ther (Heidelb), 2021
Chimalakonda A, Burke J, Cheng L, Catlett I, Tagen M, Zhao Q, Patel A, Shen J, Girgis IG, Banerjee S, Throup J.   +10 more
europepmc   +1 more source

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, EarlyView.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source

Efficacy and Safety of Ritlecitinib in the Asian Subpopulation of the ALLEGRO‐2b/3 and ALLEGRO‐LT Clinical Studies for Alopecia Areata

The Journal of Dermatology, EarlyView.
ABSTRACT Ritlecitinib is an oral JAK3/TEC family kinase inhibitor approved for individuals aged ≥ 12 years with severe alopecia areata. Here we report interim efficacy and safety results with ritlecitinib up to Month 24 in the Asian subpopulation from the ALLEGRO phase 2b/3 and ALLEGRO‐LT studies.
Rie Ueki, Masato Mizuashi, Kazutoshi Harada, Xingqi Zhang, Wenyu Wu, Wen‐Hung Chung, Ohsang Kwon, Xin Luo, Victoria Basey, Robert Wolk, Nanzhi Shi, Kayo Fujita, Yimeng Shen, Tomohiro Hirose   +13 more
wiley   +1 more source

AZD3759 enhances radiation effects in non-small-cell lung cancer by a synergistic blockade of epidermal growth factor receptor and Janus kinase-1. [PDF]

Bioengineered, 2022
Zhao R, Yin W, Yu Q, Mao Y, Deng Q, Zhang K, Ma S.   +6 more
europepmc   +1 more source

Cost‐Effectiveness Analysis of Ritlecitinib Compared With No Treatment in Patients With Severe Alopecia Areata in Japan

The Journal of Dermatology, EarlyView.
ABSTRACT The efficacy and safety of ritlecitinib, a dual inhibitor of Janus kinase 3 (JAK3) and tyrosine kinase expressed in hepatocellular carcinoma (TEC) family kinases, have been demonstrated in the ALLEGRO phase 2b/3 trial that enrolled patients aged ≥ 12 years with alopecia areata (AA) and ≥ 50% scalp hair loss.
Akira Yuasa, Kazumasa Kamei, Shota Saito, Masashi Mikami, Tatsunori Murata, Samantha Kiyomi Kurosky, Ernest H. Law, Kouki Nakamura, Rie Ueki   +8 more
wiley   +1 more source

Bridging to a selective Janus kinase 1 inhibitor in severe atopic dermatitis: An instructive case with upadacitinib. [PDF]

JAAD Case Rep, 2021
Nguyen J, Chen JK, Honari G, Pol-Rodriguez M, Ko JM, Chiou AS.   +5 more
europepmc   +1 more source