Results 161 to 170 of about 73,942 (286)

Type I interferon overactivation in sera of patients with anti‐MDA5‐positive dermatomyositis‐associated interstitial lung disease

Rheumatology &Autoimmunity, EarlyView.
Sera from patients with anti‐MDA5‐positive dermatomyositis‐associated interstitial lung disease (ILD) exhibit significantly higher type I interferon (IFN‐I) bioactivity and interferon‐stimulated gene‐inducing activity compared to anti‐ARS‐positive ILD and healthy controls.
Shohei Nakamura, Yasuhiro Katsumata, Yuko Okamoto, Masayoshi Harigai   +3 more
wiley   +1 more source

Responsive nitric oxide‐releasing antibacterial materials for biofilm‐associated infections: Mechanisms, design strategies, and applications

Responsive Materials, EarlyView.
This review summarizes the recent progress in responsive NO‐releasing materials and their applications in biofilm‐associated infectious diseases. The design principles and response mechanisms are given to provide inspiration toward the future development of multi‐responsive NO‐releasing materials.
Wenyue Sun, Meiqi Li, Di Nan, Jiaqi Zhao, Yu Chen, Yao Gao, Shichen Zhang, Kirsten L. Van Landuyt, Manlin Qi   +8 more
wiley   +1 more source

Reply: Janus kinase 1/2 inhibition with baricitinib in the treatment of juvenile dermatomyositis [PDF]

Brain, 2019
Allenbach, Yves, Bolko, Lois, Benveniste, Olivier, Toquet, Ségolène, Landon-Cardinal, Océane   +4 more
openaire   +3 more sources

Selectivity Profile of the Tyrosine Kinase 2 Inhibitor Deucravacitinib Compared with Janus Kinase 1/2/3 Inhibitors. [PDF]

Dermatol Ther (Heidelb), 2021
Chimalakonda A, Burke J, Cheng L, Catlett I, Tagen M, Zhao Q, Patel A, Shen J, Girgis IG, Banerjee S, Throup J.   +10 more
europepmc   +1 more source

Treatment Outcomes of Scleroderma with Janus Kinase Inhibitors: A Systematic Review

Scleroderma is a connective tissue disorder characterized by hardening and thickening of the skin. Initial treatment involves topical and systemic corticosteroid therapies, with immunosuppressive therapy in severe and refractory cases, although none are ...
Rijal, H (via Mendeley Data)
core   +1 more source

Modeling the lung‒brain axis in critical illness: Multifactorial crosstalk through organoids and organ‐on‐a‐chip system

VIEW, EarlyView.
Patients in intensive care units often experience lung injuries, complicated by brain problems. Advanced laboratory tools, organoids, and organs‐on‐chips facilitated the study of multiorgan interactions, help us understand the communication between the lungs and brain.
Wanyi Zhang, Ting Wang, Mengying Yao, Longxiang Su, Lixin Xie, Pan Pan   +5 more
wiley   +1 more source

Nitric Oxide Induces a Janus Kinase-1-Dependent Inflammatory Response in Primary Murine Astrocytes. [PDF]

ASN Neuro, 2021
Nowery JD, Cisney RN, Feldmann JW, Meares GP.   +3 more
europepmc   +1 more source

Treatments Outcomes of Refractory Cutaneous Scleroderma with Janus Kinase Inhibitors: A Systematic Review

Scleroderma is a connective tissue disorder characterized by hardening and thickening of the skin. Initial treatment involves topical and systemic corticosteroid therapies, with immunosuppressive therapy in severe and refractory cases, although none are ...
Rijal, H (via Mendeley Data)
core   +1 more source

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, EarlyView.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source

Janus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase.

The Journal of biological chemistry, 2004
The Janus kinases are considered to be cytoplasmic kinases that constitutively associate with the cytoplasmic region of cytokine receptors, and the Janus kinases (Jaks) are crucial for cytokine signal transduction. We investigated Jak1 localization using subcellular fractionation techniques and fluorescence microscopy (immunofluorescence and yellow ...
Behrmann, Iris, Smyczek, Tanya, Heinrich, Peter, Schmitz-Van de Leur, Hildegard, Komyod, Waraporn, Giese, Bernd, Müller-Newen, Gerhard, Haan, Serge, Haan, Claude   +8 more
openaire   +3 more sources