Bridging to a selective Janus kinase 1 inhibitor in severe atopic dermatitis: An instructive case with upadacitinib. [PDF]
JAAD Case Rep, 2021 Nguyen J +5 more
europepmc +1 more source
The Journal of Dermatology, EarlyView.ABSTRACT Upadacitinib (UPA) is a selective Janus kinase 1 inhibitor that improves moderate‐to‐severe atopic dermatitis, but real‐world strategies to maintain remission after response remain unclear. We conducted a multicenter retrospective study in Japan of 219 patients aged ≥ 12 years who achieved protocol‐defined remission, defined as Investigator's ...
Yuichiro Tsunemi +3 more
wiley +1 more source
Refractory nail lichen planus treated successfully with the Janus kinase 1 inhibitor abrocitinib: A case report. [PDF]
J Int Med ResWang L, Lei X, Li L, Cheng Q.
europepmc +1 more source
AZD3759 enhances radiation effects in non-small-cell lung cancer by a synergistic blockade of epidermal growth factor receptor and Janus kinase-1. [PDF]
Bioengineered, 2022 Zhao R +6 more
europepmc +1 more source
Identifying the Role of Janus Kinase 1 in Mammary Gland Development and Breast Cancer
, 2017 The development of the postnatal mammary gland is tightly controlled by peptide hormones and cytokines. The signaling of these extracellular ligands through their corresponding receptors rely on Janus Kinases (JAKs) that activate downstream Signal ...
Swenson, Barbara
core
Guselkumab Safety in Patients With Latent Tuberculosis: Analysis of 11 Studies in Psoriatic Disease
The Journal of Dermatology, EarlyView.ABSTRACT Certain psoriatic disease treatments, including tumor necrosis factor‐α inhibitors (TNFi), increase tuberculosis (TB) risk. Testing for latent TB infection (LTBI) before initiating systemic therapy has been standard practice for psoriasis (PsO) patients; however, updated consensus states routine testing is not required before initiating ...
Luis Puig +14 more
wiley +1 more source
The Journal of Dermatology, EarlyView.ABSTRACT Atopic dermatitis is a chronic inflammatory skin disease that commonly begins in childhood but exhibits heterogeneous long‐term clinical courses. We conducted a cross‐sectional questionnaire survey among dermatologists to evaluate age‐specific prevalence, remission proportion, severity, and disease course of atopic dermatitis in Japan.
Takeshi Nakahara +11 more
wiley +1 more source
Rheumatoid Arthritis Preceded by Interstitial Lung Disease Controlled by Long-Term Treatment With the Janus Kinase 1-Selective Inhibitor, Filgotinib: A Case Report. [PDF]
Respirol Case RepSato T +4 more
europepmc +1 more source
Jak out of the box: Targeting Bruton's tyrosine kinase, sialic acid-binding immunoglobulin-like lectin-8, and Janus kinase 1 in food allergy. [PDF]
Ann Allergy Asthma Immunol, 2023 Berin C.
europepmc +1 more source
The Journal of Dermatology, EarlyView.ABSTRACT This retrospective study evaluated the clinical courses and treatment patterns of 81 patients with atopic dermatitis (AD) treated with dupilumab at Hiroshima University Hospital. Patients were categorized into six groups based on their clinical outcomes, including those who continued treatment, achieved remission and discontinued, or ...
Ryo Saito +6 more
wiley +1 more source