Results 191 to 200 of about 73,942 (286)

Circular RNA PIP5K1A act as microRNA-552-3p sponge to regulates inflammation, oxidative damage in glucolipotoxicity-induced pancreatic INS-1 β-cells via Janus kinase 1. [PDF]

Bioengineered, 2022
Ren L.
europepmc   +1 more source

Early Epidemiologic and Immune Predictors of Atopic Dermatitis: Reduced Cord Blood Regulatory B10 Cells in the Munich Atopy Prediction Study (MAPS)

Allergy, EarlyView.
In this prospective birth cohort from Munich, comprehensive clinical assessments and longitudinal lifestyle questionnaires were combined with cord blood immune profiling. Infants who later developed AD showed altered cord blood immune signatures, including reduced CD4+ T cells, increased B cells and markedly decreased Breg cells. Epidemiologic factors,
S. Preis, S. Kaesler, M. Koeberle, M. Hils, B. Evers, R. L. Silva, Y. Skabytska, L. Schellenberger, H. Hufnagel, M. Schielein, B. Kuschel, Y. Amar, A. Zink, T. Biedermann, Z. Kurgyis   +14 more
wiley   +1 more source

Cardiomyocyte Janus kinase 1 (JAK1) signaling is required for cardiac homeostasis and cytokine-dependent activation of STAT3. [PDF]

J Mol Cell Cardiol
Subramani A, Essandoh K, Young MY, Marino FH, Teuber JP, Wagner KU, Brody MJ.   +6 more
europepmc   +1 more source

Characterization and analysis of the proximal Janus kinase 3 promoter

, 2003
Janus kinase 3 (Jak3) is a nonreceptor tyrosine kinase essential for signaling via cytokine receptors that comprise the common ϒ-chain (ϒc), i.e., the receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21.
Frucht, David M., Hofmann, Sigrun R., Visconti, Roberta, O'Shea, John J., Kastner, Daniel L., Smolen, Josef S., Chen, Min, Aringer, Martin, Morinobu, Akio, Centola, Michael   +9 more
core  

The Role of Janus Kinase 1 in TGF-Beta 1 Induced Fibroblast Trans-Differentiation [PDF]

B64. MECHANISTIC ADVANCES IN LUNG FIBROSIS, 2020
F.-P. Wang, S. Wang, E.L. Matteson, D.J. Tschumperlin, R. Vassallo   +4 more
openaire   +1 more source

Efficacy and safety of Janus kinase 1/2 inhibitor KL130008 in active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase II trial. [PDF]

BMC Med
Cheng Y, Tang H, Qing Y, Liu Y, Yang L, Dang W, Yu J, Li R, Liu H, Jiang Z, Sun H, Yin S, Cheng J, Li Z, Fan W, Zhang H, Du H, Fu Z, Ma X, Wu J, Duan L, Zhang R, Lin J, Da Z, Wei W, Zhai Q, Wu B, Yi X, Jin X, Ge J, Feng P, Liu Y.   +31 more
europepmc   +1 more source

Efficacy and Safety of SHR0302, a Highly Selective Janus Kinase 1 Inhibitor, in Patients with Moderate to Severe Atopic Dermatitis: A Phase II Randomized Clinical Trial. [PDF]

Am J Clin Dermatol, 2021
Zhao Y, Zhang L, Ding Y, Tao X, Ji C, Dong X, Lu J, Wu L, Wang R, Lu Q, Goh AH, Liu R, Zhang Z, Zhang J.   +13 more
europepmc   +1 more source

Exploring market dynamics of biological including biosimilar treatments for retinal diseases in Europe: An interrupted time‐series analysis

Acta Ophthalmologica, EarlyView.
Abstract Purpose To assess the impact of biosimilar ranibizumab and on‐patent faricimab market entry on pricing and utilization trends and describe national variation in off‐label bevacizumab use in Europe. Methods Interrupted time series analysis of quarterly sales data (Q1 2018–Q2 2024) in 11 European countries evaluated ranibizumab utilization and ...
Elif Car, Isabelle Huys, Steven Simoens, Arnold G. Vulto   +3 more
wiley   +1 more source

Parallel Inhibition of Interleukin 4 (IL-4)/Interleukin 13 (IL-13) and Janus Kinase 1 (JAK1) in Atopic Dermatitis: Beyond the Traditional Biologic Paradigm. [PDF]

Cureus
Perez-Romero AG, Rangel MA, Crocker Sandoval AB, Ruiz Leon M, Aceves M.   +4 more
europepmc   +1 more source

Incidence of Hepatitis B Virus Reactivation in Patients Treated With Immunosuppressive and Chemotherapeutic Agents

Alimentary Pharmacology &Therapeutics, EarlyView.
HBV reactivation incidence varied across immunosuppressive and chemotherapeutic agents. Clinically meaningful HBV reactivation was also observed in patients receiving corticosteroids and conventional immunosuppressive therapies. ABSTRACT Background Data on the incidence of hepatitis B virus reactivation (HBVr) remain limited. In Japan, patients who are
Kazuhiko Ikeuchi, Makoto Saito, Kazuya Okushin, Toshiyuki Kishida, Akira Kado, Kyoji Moriya, Kazuhiko Koike, Takeya Tsutsumi, Hiroshi Yotsuyanagi   +8 more
wiley   +1 more source