Results 201 to 210 of about 107,749 (252)

Minimal Disease Activity as A New Therapeutic Target in Atopic Dermatitis: A 5‐Year Real‐Life Experience With Dupilumab

International Journal of Dermatology, EarlyView.
ABSTRACT Background Atopic dermatitis (AD) is a chronic inflammatory skin disease with significant physical and psychosocial burden. Dupilumab, a monoclonal antibody targeting IL‐4Rα, has proven to be effective for moderate‐to‐severe AD, but long‐term real‐world data remain limited.
Francesco Leo, Luca Mastorino, Luca Cangialosi, Davide Favre, Chiara Anna Fiasconaro, Yingying Liao, Federico Goso, Niccolò Siliquini, Giovanni Cavaliere, Pietro Quaglino, Simone Ribero, Michela Ortoncelli   +11 more
wiley   +1 more source

Embryonic stem cells and nuclear transfer strategies - Present state and future prospects [PDF]

, 2000
Beier, Henning M., Wobus, Anna M., Wolf, Eckhard   +2 more
core   +1 more source

Epidemiology, Diagnosis and Management of Alopecia Areata: An Asia‐Pacific Modified Delphi Expert Panel Recommendations

International Journal of Dermatology, EarlyView.
A panel of 18 dermatologists participated in a three‐round Delphi‐based consensus process to generate a standardized framework for the diagnosis and management of alopecia areata (AA) in Asia Pacific. Recommendations focus on practicality and clinical relevance within the regional context.
Rodney Sinclair, Chao‐Chun Yang, Wen‐Hung Chung, Rachita Dhurat, Anil Ganjoo, Saranya Khunkhet, Jinran Lin, Anchala Parthasaradhi, Hyun‐Tae Shin, Kihyuk Shin, Poonkiat Suchonwanit, Kian Teo Tan, Jyh Jong Tang, Wenyu Wu, Felix Boon‐Bin Yap, Leona Yip, Angeline Yong, Cheng Zhou   +17 more
wiley   +1 more source

JAK inhibitors and menstrual cycle alterations: insights from a case series of 16 female patients

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Luciano Ibba, Luigi Gargiulo, Matteo Bianco, Sara Di Giulio, Ruggero Cascio Ingurgio, Angela Alfano, Carlo A. Vignoli, Mario Valenti, Paola Facheris, Chiara Perugini, Alessandra Narcisi, Antonio Costanzo   +11 more
wiley   +1 more source

Multilingual Digital Search Behavior Reveals Cultural Disparities in Vitiligo Information Needs in Germany

International Journal of Dermatology, EarlyView.
Multilingual vitiligo‐related Google search queries in Germany (October 2019–May 2023) were extracted and thematically coded across German, English, Turkish, Arabic, Russian, and Polish. Relative patterns highlighted language‐specific emphases in treatment information, camouflage, depigmentation, psychosocial burden, and faith/home‐remedy terms ...
Lilian Rauch, Christine Gasteiger, Markus Böhm, Georg Pliszewski, Tilo Biedermann, Alexander Zink   +5 more
wiley   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Janus kinase 1/2 inhibition with baricitinib in the treatment of juvenile dermatomyositis. [PDF]

Brain, 2019
Papadopoulou C, Hong Y, Omoyinmi E, Brogan PA, Eleftheriou D.   +4 more
europepmc   +1 more source

Signal Transducer and Activator of Transcription (STAT) Proteins Regulate Mucosal‐Associated Invariant T (MAIT) Cell Function

Immunology, EarlyView.
Integrated transcriptomic, proteomic and flow cytometry analyses reveal that STAT1 negatively regulates MAIT cell effector and glycolytic functions, while STAT3, STAT5 and HIF1α act as positive modulators. Targeting these pathways may offer new strategies to restore MAIT cell function in immune dysregulation and cancer.
Olivia J. Cheng, Eimear K. Ryan, Michael Bennett, Christy Clutter, Jackson G. Cacioppo, Jeffrey Aubé, Andy E. Hogan, Daniel T. Leung   +7 more
wiley   +1 more source

USP18 mediates high glucose‐induced cardiomyocyte injury by regulating the JAK/STAT signaling pathway through stabilizing FOXC2 expression

Journal of Diabetes Investigation, EarlyView.
USP18 upregulation stabilizes FOXC2 expression by deubiquitination to inactivate the JAK2/STAT3 pathway, thereby inhibiting HG‐induced NMVM apoptosis, inflammation, oxidative stress, and fibrosis. ABSTRACT Background Cardiomyopathy is one of the complications of diabetes, among which myocardial fibrosis is the most typical feature.
Zhengrong Xu, Weidong Ren, Jun Gu, Wenjuan Deng, Lijuan Zuo   +4 more
wiley   +1 more source

Untangle a Broken Heart via Janus Kinase 1. [PDF]

Circ Res, 2017
Gao C, Wang Y.
europepmc   +1 more source