Allergy, EarlyView.In this prospective birth cohort from Munich, comprehensive clinical assessments and longitudinal lifestyle questionnaires were combined with cord blood immune profiling. Infants who later developed AD showed altered cord blood immune signatures, including reduced CD4+ T cells, increased B cells and markedly decreased Breg cells. Epidemiologic factors,
S. Preis +14 more
wiley +1 more source
Quercetin pretreated umbilical cord mesenchymal stem cells alleviate inflammatory bowel disease <i>via</i> IL-10 /Janus kinase 2/STAT3 signaling. [PDF]
World J Stem CellsShi MY, Liu L, Yang FY.
europepmc +1 more source
British Journal of Haematology, EarlyView.Fostamatinib had 46% durable response, with 73% steroid reduction, in this multicentre retrospective study of refractory wAIHA/ES. Hypertension, gastrointestinal (GI) distress and neutropenia occurred in 23%. Only one patient required drug discontinuation and one patient dose reduction.
Jorge N. Ruiz Lopez +16 more
wiley +1 more source
The Janus kinase 2 (JAK2) Mutation Burden is Related to Hematological Outcomes in Thai Patients with Myeloproliferative Neoplasms. [PDF]
Asian Pac J Cancer PrevSritana N +5 more
europepmc +1 more source
Efficiently Restored Thrombopoietin Production by Ashwell-Morell Receptor and IL-6R Induced Janus Kinase 2/Signal Transducer and Activator of Transcription Signaling Early After Partial Hepatectomy. [PDF]
Hepatology, 2021 Reusswig F +11 more
europepmc +1 more source
Assay Development and Inhibitor Screening for Janus Kinase 2
, 2023 Janus kinase 2 (JAK2) is an essential mediator of hematopoietic and growth signaling in cells. It signals as a part of the Janus kinase and signal transducer and activator of transcription (JAK-STAT) pathway, which ultimately regulates gene expression by mediating cytokine signaling from a diverse set of cytokines.
openaire +1 more source
Cytoreductive nephrectomy in the era of immune‐checkpoint inhibitors: back to the future?
BJU International, EarlyView.Objective To investigate the role of cytoreductive nephrectomy (CN) in metastatic renal cell carcinoma (mRCC) treated with immune‐checkpoint inhibitors (ICIs). Methods A narrative review was carried out using PubMed and searching for English articles published from January 2015 to May 2025.
Rocco Simone Flammia +8 more
wiley +1 more source
Janus kinase 2 (JAK2); histone deacetylase (HDAC) [PDF]
Science-Business eXchange, 2009 openaire +1 more source
Opioids in breast cancer: Between analgesia and modulation of tumour progression
British Journal of Pharmacology, EarlyView.Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun +2 more
wiley +1 more source