Results 211 to 220 of about 457,473 (371)

Association of Janus kinase 2 polymorphisms with growth and reproduction traits in chickens

, 2010
Wenyao Liu, Dongxiao Sun, Ying Yu, Guoming Li, S.Q. Tang, Ying Zhang, Y. Zhang, Y.C. Wang, Y. Zhang, Y. Zhang   +9 more
openalex   +1 more source

A phase 1 study of the Janus kinase 2 (JAK2)V617F inhibitor, gandotinib (LY2784544), in patients with primary myelofibrosis, polycythemia vera, and essential thrombocythemia.

Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis, 2017
S. Verstovsek, R. Mesa, M. Salama, Li Li, C. Pitou, F. Nunes, G. Price, J. Giles, D. D'souza, R. Walgren, J. Prchal   +10 more
semanticscholar   +1 more source

Assay Development and Inhibitor Screening for Janus Kinase 2

, 2023
Janus kinase 2 (JAK2) is an essential mediator of hematopoietic and growth signaling in cells. It signals as a part of the Janus kinase and signal transducer and activator of transcription (JAK-STAT) pathway, which ultimately regulates gene expression by mediating cytokine signaling from a diverse set of cytokines.
openaire   +1 more source

Type I interferon overactivation in sera of patients with anti‐MDA5‐positive dermatomyositis‐associated interstitial lung disease

Rheumatology &Autoimmunity, EarlyView.
Sera from patients with anti‐MDA5‐positive dermatomyositis‐associated interstitial lung disease (ILD) exhibit significantly higher type I interferon (IFN‐I) bioactivity and interferon‐stimulated gene‐inducing activity compared to anti‐ARS‐positive ILD and healthy controls.
Shohei Nakamura, Yasuhiro Katsumata, Yuko Okamoto, Masayoshi Harigai   +3 more
wiley   +1 more source

Novel Therapeutics for Chronic Obstructive Pulmonary Disease: From Empirical Bronchodilation to Precision Medicine

Respirology, EarlyView.
ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley   +1 more source

Janus Kinase-2 Mutation Associated Portal Vein Thrombosis Complicating Liver Cirrhosis and Hepatocellular Carcinoma. [PDF]

Asian Pac J Cancer Prev, 2021
Rabie H, Othman W, Elsabaawy DM, Elshemy EE, Abdelmageed N, Khalaf FA, Bedair HM.   +6 more
europepmc   +1 more source

Modeling the lung‒brain axis in critical illness: Multifactorial crosstalk through organoids and organ‐on‐a‐chip system

VIEW, EarlyView.
Patients in intensive care units often experience lung injuries, complicated by brain problems. Advanced laboratory tools, organoids, and organs‐on‐chips facilitated the study of multiorgan interactions, help us understand the communication between the lungs and brain.
Wanyi Zhang, Ting Wang, Mengying Yao, Longxiang Su, Lixin Xie, Pan Pan   +5 more
wiley   +1 more source

Enhancer of zeste homolog 2 contributes to apoptosis by inactivating janus kinase 2/ signal transducer and activator of transcription signaling in inflammatory bowel disease. [PDF]

World J Gastroenterol, 2021
Zhou J, Yang Y, Wang YL, Zhao Y, Ye WJ, Deng SY, Lang JY, Lu S.   +7 more
europepmc   +1 more source

Analysis of Oncogenic Signaling Pathway Induced by a Myeloproliferative Neoplasm-associated Janus Kinase 2 (JAK2) V617F Mutant

, 2012
Megumi Funakoshi‐Tago
openalex   +2 more sources

Supplementary Figures 1-4 from Prolyl Isomerase Cyclophilin A Regulation of Janus-Activated Kinase 2 and the Progression of Human Breast Cancer

, 2023
Jiamao Zheng, Jennifer E. Koblinski, Laura V. Dutson, Yvonne B. Feeney, Charles V. Clevenger   +4 more
openalex   +1 more source