Results 231 to 240 of about 70,715 (255)

Downregulation of Chloride Channel ClC-2 by Janus Kinase 3

The Journal of Membrane Biology, 2014
Janus kinase-3 (JAK3) fosters proliferation and counteracts apoptosis of lymphocytes and tumor cells. The gain of function mutation (A572V)JAK3 has been discovered in acute megakaryoplastic leukemia. JAK3 is inactivated by replacement of lysine by alanine in the catalytic subunit ((K855A)JAK3).
Jamshed, Warsi, Bernat, Elvira, Zohreh, Hosseinzadeh, Ekaterina, Shumilina, Florian, Lang   +4 more
openaire   +2 more sources

Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

MedChemComm, 2012
Cyclometalated rhodium complexes were synthesized and evaluated as JAK2 metal-based inhibitors. Complexes 1 and 2 inhibited JAK2 enzyme phosphorylation activity, reduced JAK2 autophosphorylation in cellulo and exhibited cytotoxicity towards HEL cancer cells. To our knowledge, these are the first two examples of metal-based inhibitors of JAK2.
Chung-Hang Leung, Hui Yang, Victor Pui-Yan Ma, Daniel Shiu-Hin Chan, Hai-Jing Zhong, Ying-Wei Li, Wang-Fun Fong, Dik-Lung Ma   +7 more
openaire   +1 more source

Expression, purification, and characterization of TYK-2 kinase domain, a member of the Janus kinase family

Biochemical and Biophysical Research Communications, 2010
The Janus kinase family consists of four members: JAK-1, -2, -3 and TYK-2. While JAK-2 and JAK-3 have been well characterized biochemically, there is little data on TYK-2. Recent work suggests that TYK-2 may play a critical role in the development of a number of inflammatory processes.
Brian, Korniski, Arthur J, Wittwer, Thomas L, Emmons, Troii, Hall, Stacy, Brown, Ann D, Wrightstone, Jeffrey L, Hirsch, Jennifer A, Gormley, Robin A, Weinberg, Joseph W, Leone, Jacqueline E, Day, Jill E, Chrencik, Cynthia D, Sommers, H David, Fischer, Alfredo G, Tomasselli   +14 more
openaire   +2 more sources

Structural basis of Janus kinase trans-activation

Cell Reports, 2023
Kenan Garcia, Stevan Hubbard, Caleb Glassman   +2 more
exaly  

Potential Use of Janus Kinase Inhibitors in the Treatment of Systemic Lupus Erythematosus

Journal of Inflammation Research, 2023
Xinxiang Huang, Jinying Lin
exaly  

Repigmentation in vitiligo using janus kinase (JAK) inhibitors with phototherapy: systematic review and Meta-analysis

Journal of Dermatological Treatment, 2022
Kevin Phan, Steven Phan
exaly  

The Use of Janus Kinase Inhibitors in Axial Spondyloarthritis: Current Insights

Pharmaceuticals, 2022
Eric Toussirot, Toussirot Eric
exaly  

The Era of Janus Kinase Inhibitors for Inflammatory Bowel Disease Treatment

International Journal of Molecular Sciences, 2021
Su Young Kim
exaly  

<p>Emerging Role of Janus Kinase Inhibitors for the Treatment of Atopic Dermatitis</p>

ImmunoTargets and Therapy, 2020
Rima Ghamrawi, Steven Feldman, Courtney Heron   +2 more
exaly  

Janus kinase inhibitors in dermatology: Part II. A comprehensive review

Journal of the American Academy of Dermatology, 2022
Henry Wan-Peng Lim, Linda Stein Gold, Stephanie Chapman   +2 more
exaly