Results 291 to 300 of about 399,504 (355)

Targeting Overexpressed IDO in Stromal Cells as a Potential Therapeutic Strategy in Multiple Myeloma

Cancer Science, EarlyView.
IDO expression in stromal cells was upregulated by MM cells via the JAK–STAT1–NF‐κB–IRF1 signaling pathway. JAK inhibitor abolished IDO and IRF1 upregulation. ABSTRACT Stromal cells are an essential component of the tumor microenvironment (TME) in multiple myeloma (MM). Indoleamine 2,3‐dioxygenase 1 (IDO), an enzyme that metabolizes tryptophan (Trp) to
Toru Ebina, Masaki Ri, Yoshiaki Marumo, Tomoyuki Nakamura, Hirokazu Sasaki, Yoshiko Oshima, Takahiro Nakashima, Shinya Hagiwara, Arisa Asano, Shiori Kinoshita, Tomotaka Suzuki, Tomoko Narita, Ayako Masaki, Takaomi Sanda, Kazufumi Yamagata, Kohmei Kubo, Hirokazu Komatsu, Hirotake Sakuraba, Shinsuke Iida   +18 more
wiley   +1 more source

Drug Survival in Atopic Dermatitis: Comparison of Biologics and JAK Inhibitors in the BioDay Registry

Allergy, EarlyView.
Lian F. van der Gang, Celeste M. Boesjes, Nicolaas P. A. Zuithoff, Inge Haeck, Octavian Bacoş‐Cosma, Laura Loman, Keneshka Atash, Veroniek Harbers, Simone Stadhouders, Albert J. Oosting, Anneke M. T. van Lynden‐van Nes, Klaziena Politiek, Antoni Gostynski, Wianda A. Christoffers, Floor M. Garritsen, Annebeth Flinterman, Wouter R. H. Touwslager, Berit Velstra, Shiarra M. Stewart, Francine C. van Erp, Annemie F. S. Galimont‐Collen, Marie‐Louise A. Schuttelaar, Marlies de Graaf, Marjolein S. de Bruin‐Weller   +23 more
wiley   +1 more source

Circular ribonucleic acid 0004104 as a potential biomarker and its relation to Janus kinase 2 in ulcerative colitis [PDF]

Roaa Tarek Elbannan, H Abdel-Aziz, Eman Shaat, Ibrahim Am, Hend H. Yassin   +4 more
openalex   +1 more source

Heat shock protein 90 (Hsp90); janus kinase-2 (JAK-2) [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

Well‐being in German patients with vitiligo in genital and visible areas – a pilot study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background Only a few studies exist on the psychosocial impact of vitiligo in German patients, in particular those affected in genital and visible body areas. Methods This monocentric pilot study aimed to assess well‐being of adult patients with vitiligo and to compare sex, age, and clinical characteristics between patients with and without ...
Janne Ohlenbusch, Rachel Sommer, Kerstin Steinbrink, Markus Böhm   +3 more
wiley   +1 more source

Janus kinase 2 activation mechanisms revealed by analysis of suppressing mutations. [PDF]

J Allergy Clin Immunol, 2019
Hammarén HM, Virtanen AT, Abraham BG, Peussa H, Hubbard SR, Silvennoinen O.   +5 more
europepmc   +1 more source

S1‐Guideline for diagnosis and therapy of necrobiosis lipoidica

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Necrobiosis lipoidica (NL) is a rare granulomatous skin disease of unknown etiology that occurs frequently in association with diabetes mellitus and other comorbidities. The predilection site is the lower leg, particularly the pretibial areas. The exact pathogenesis remains unclear.
Cornelia Erfurt‐Berge, Regina Renner, Melanie Peckruhn, Jörg Tittelbach, Dorothea Terhorst‐Molawi, Friederike Kauer, Joachim Dissemond   +6 more
wiley   +1 more source

Janus Kinase 2/Signal Transducer and Activator of Transcription 3/Cyclooxygenase 2 Signaling Pathway Mediates the Effect of Central Angiotensin II on the Elevation of Rostral Ventrolateral Medulla Prostaglandin E ₂ ‐Induced Oxidative Stress in Hypertension

Jie‐Fu Fan, Xing Tan, Wen Wang, Ji‐Kui Li, Yunqi Xiao, Weizhong Wang, Yang‐Kai Wang   +6 more
openalex   +1 more source

Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15.

, 1995
J A Johnston, Chris M. Bacon, D S Finbloom, Robert C. Rees, Daniel H. Kaplan, Kenji Shibuya, John R. Ortaldo, Shan R. Gupta, Y Q Chen, Jayeeta Giri   +9 more
openalex   +2 more sources

Toll-Like Receptor 4-Linked Janus Kinase 2 Signaling Contributes to Internalization of Brucella abortus by Macrophages

Infection and Immunity, 2013
J. Lee, Dong Hyeok Kim, D. Kim, Hu-Jang Lee, W. Min, M. Rhee, J. Cho, M. Watarai, Suk Kim   +8 more
semanticscholar   +1 more source