Leukemia Inhibitory Factor Represses GnRH Gene Expression via cFOS during Inflammation in Male Mice. [PDF]
, 2019 BackgroundThe mechanisms whereby neuroinflammation negatively affects neuronal function in the hypothalamus are not clear. Our previous study determined that obesity-mediated chronic inflammation elicits sex-specific impairment in reproductive function ...
Coss, Djurdjica, Lainez, Nancy M
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Insight into Janus kinases specificity: From molecular architecture to cancer therapeutics
MedComm – OncologyJanus Kinases (JAKs) play a crucial role as therapeutic targets for various cancers. However, the current JAK inhibitors (JAKi) available have limited therapeutic benefits due to their lack of selectivity.
Tian‐Hua Wei +18 more
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Janus kinases restrain chronic lymphocytic leukemia cells in patients on ibrutinib: Results of a phase II trial. [PDF]
Cancer Med, 2021 Spaner DE +5 more
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Narrow spectrum kinase inhibitors demonstrate promise for the treatment of dry eye disease and other ocular inflammatory disorders [PDF]
, 2018 Doughty, Michael +11 more
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Inhibitors Targeting Multiple Janus Kinases From Zanthoxylum simulans Mediate Inhibition and Apoptosis Against Gastric Cancer Cells via the Estrogen Pathway. [PDF]
Front Chem, 2022 Tian YQ +5 more
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Pseudorabies Virus Inhibits Type I and Type III Interferon-Induced Signaling via Proteasomal Degradation of Janus Kinases. [PDF]
J Virol, 2021 Yin Y, Romero N, Favoreel HW.
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The role of Janus kinase signaling in graft-versus-host disease and graft versus leukemia [PDF]
, 2018 Choi, Jaebok +3 more
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Structure, function and inhibition of poly(ADP-ribose)polymerase, member 14 (PARP14) [PDF]
, 2018 Levonis, Stephan M +3 more
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Characterization of Jak, STAT, and Src interactions in Head and Neck Squamous Cell Carcinoma [PDF]
, 2013 Recurrence of Head and Neck Squamous Cell Carcinoma (HNSCC) is common; thus, it is essential to improve the effectiveness and reduce toxicity of current treatments.
Jaseja, Reshma, Jaseja, Reshma
core
Effect of JAK inhibitors on release of CXCL9, CXCL10 and CXCL11 from human airway epithelial cells [PDF]
, 2015 Barnes, PJ +3 more
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