Clinical significance of Janus Kinase inhibitor selectivity [PDF]
, 2019 Cytokines are key drivers of inflammation in RA, and anti-cytokine therapy has improved the outcome of RA. Janus Kinases (JAK) are intracellular tyrosine kinases linked to intracellular domains of many cytokine receptors.
Choy, Ernest H
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Janus kinase inhibitors role in bone remodeling [PDF]
, 2019 Janus kinases (JAKs) play a pleiotropic role in several important physiological processes, such as cell maturation, cell proliferation, and cell death, via providing transmission signals from several molecules, such as cytokines, interferons, hormones ...
Cantatore F. P. +3 more
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JAK inhibitors: a new choice for diabetes mellitus?
Diabetology & Metabolic SyndromeAltered tyrosine kinase signaling is associated with a variety of diseases. Tyrosine kinases can be classified into two groups: receptor type and nonreceptor type. Nonreceptor-type tyrosine kinases are subdivided into Janus kinases (JAKs), focal adhesion
Mengjun Zhou, Qi Shen, Bo Li
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Filamins but not Janus kinases are substrates of the ASB2α cullin-ring E3 ubiquitin ligase in hematopoietic cells. [PDF]
, 2012 The ASB2α protein is the specificity subunit of an E3 ubiquitin ligase complex involved in hematopoietic differentiation and is proposed to exert its effects by regulating the turnover of specific proteins.
Lutz, Pierre +7 more
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Mechanistic Insights into Regulation of JAK2 Tyrosine Kinase
Frontiers in Endocrinology, 2018 JAK2 is a member of the Janus kinase (JAKs) family of non-receptor protein tyrosine kinases, which includes JAK1–3 and TYK2. JAKs serve as the cytoplasmic signaling components of cytokine receptors and are activated through cytokine-mediated trans ...
Stevan R. Hubbard
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Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation [PDF]
, 2000 Cytokines play a critical role in the normal development and function of the immune system. On the other hand, many rheumatologic diseases are characterized by poorly controlled responses to or dysregulated production of these mediators.
Visconti, Roberta +4 more
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Janus kinase inhibitors for alopecia areata: a review of clinical data
Frontiers in ImmunologyAlopecia areata (AA) is an autoimmune disease characterized by inflammatory and non-scarring hair loss, mediated by CD8+ T cells and primarily affecting hair follicles.
Yutong Sun +3 more
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The Pim kinases: new targets for drug development [PDF]
, 2011 The three Pim kinases are a small family of serine/threonine kinases regulating several signaling pathways that are fundamental to cancer development and progression.
Mahalingam, Devalingam +7 more
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Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy
Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
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Lymphoid malignancies: another face to the Janus kinases [PDF]
, 2013 Considerable attention has focused on the gain-of-function mutations in the Janus kinase-2 (JAK2) tyrosine kinase that are detectable in most patients with a myeloproliferative neoplasm.
Linda M. Scott, Scott, Linda M.
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