Results 191 to 200 of about 30,431 (245)

Engineered Fenretinide- and Tocilizumab-Releasing Janus Nanoparticles for Site-Directed Immunochemoprevention of Squamous Cell Carcinoma of the Lung. [PDF]

Pharmaceutics
Wang D, Chang A, Shea F, He Y, Spinney R, Whitsett JD, Lahann J, Mallery SR.   +7 more
europepmc   +1 more source

Successful Management of Persistent DRESS with Tofacitinib: Two Case Reports

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Marc Hernández‐Santacana, Ignasi Martí‐Martí, Victoria Amat‐Samaranch, Irene Fuertes de Vega, Priscila Giavedoni, José M. Mascaró Jr   +5 more
wiley   +1 more source

Chemotherapy-Induced Alopecia Beyond Cytotoxicity: Hair Follicle Immune Privilege Collapse and JAK-STAT Signaling. [PDF]

Int J Mol Sci
Wang PC, Yu S.
europepmc   +1 more source

Diversifying the triquinazine scaffold of a Janus kinase inhibitor. [PDF]

RSC Med Chem
Mulliri K, Meier K, Feuchter JD, Javor S, Meirelles MA, Reymond JL.   +5 more
europepmc   +1 more source

Molecular basis and cellular effects of Janus-class-driven cytoplasmic PYK2 coacervates. [PDF]

Commun Biol
Colombo G, Salem I, Szczepski K, Yu P, Alfaiyz S, Guzmán-Vega FJ, Abogosh A, Kulmanov M, Al-Harthi S, Kadaré G, Hoehndorf R, Girault JA, Jaremko Ł, Momin AA, Arold ST.   +14 more
europepmc   +1 more source

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Janus kinase-1 and Janus kinase-2 inhibitors for treating myelofibrosis

Cochrane Database of Systematic Reviews, 2015
Myelofibrosis is a bone marrow disorder characterized by excessive production of reticulin and collagen fiber deposition caused by hematological and non-hematological disorders. The prognosis of myelofibrosis is poor and treatment is mainly palliative.
Arturo J, Martí-Carvajal, Vidhu, Anand, Ivan, Solà   +2 more
openaire   +4 more sources

Janus Kinase Mutations

Seminars in Oncology, 2009
The chronic myeloproliferative neoplasms (MPNs) polycythemia vera (PV), essential thrombocytosis (ET), and primary myelofibrosis (MF) are commonly associated with mutations in the Janus kinase gene JAK2. A hallmark of PV is an abundance of red blood cells; ET, too many platelets; and MF, accumulation of neutrophils and monocytes accompanied by bone ...
openaire   +2 more sources

The many faces of Janus kinase

Biochemical Pharmacology, 2012
Janus kinases have proved to be essential for many immunological processes but there is growing evidence that they also play a critical role in pathogenesis of many diseases including inflammatory diseases and cancer where they promote multiple steps of tumorigenesis.
Matthew M, Seavey, Pawel, Dobrzanski
openaire   +2 more sources