Results 231 to 240 of about 55,676 (335)

Club Cells in Nasal Epithelial Repair: Insights From an IL‐13‐Induced Inflammatory Model

Allergy, EarlyView.
Four inflammatory endotypes of CRSwNP, defined by eosinophil and neutrophil infiltration, show distinct patterns of basal, club, ciliated, and goblet cell expression in nasal epithelium. Using an ALI‐HNECs model, we demonstrate that IL‐13 impairs mucociliary function by promoting club‐to‐goblet cell differentiation while inhibiting club‐to‐ciliated ...
Zhi‐Qun Huang, Jing Liu, Jing Ye, Li‐Ying Sun, Hsiao Hui Ong, Yang Peng, Bing‐Qi Lin, Jun‐Hao Tu, Ke‐Shuang Wang, Yi‐Shan Xiong, Qing Luo, Mark Thong, Yu Xu, De‐Yun Wang   +13 more
wiley   +1 more source

On the Mechanism of Action of Anti-Inflammatory Activity of Hypericin: An In Silico Study Pointing to the Relevance of Janus Kinases Inhibition. [PDF]

Molecules, 2018
Dellafiora L, Galaverna G, Cruciani G, Dall'Asta C, Bruni R.   +4 more
europepmc   +1 more source

Targeting Immunologic Pathways in Eosinophilic Granulomatosis With Polyangiitis: Translating Emerging Evidence Into Clinical Practice

Allergy, EarlyView.
ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and potentially life‐threatening systemic, inflammatory disease with multi‐organ manifestations, variable presentation and complex pathology. Multiple interconnected immunological pathways are implicated in EGPA pathology, including a type‐2 immune response driving predominantly ...
Harold Wilson‐Morkeh, Lior Seluk, Philipp Bosch, Carolina Aguiar, Jens Thiel, Bernhard Hellmich, Michael E. Wechsler, Salman Siddiqui   +7 more
wiley   +1 more source

Comparative safety of oral Janus kinase inhibitors versus dupilumab in patients with atopic dermatitis: A population-based cohort study [PDF]

Serena Yun‐Chen Tsai, Wanda Phipatanakul, Elena B. Hawryluk, Michiko K. Oyoshi, Lynda C. Schneider, Kevin Sheng‐Kai   +5 more
openalex   +1 more source

Janus Kinases Affect Thrombopoietin Receptor Cell Surface Localization and Stability [PDF]

, 2005
Yohan Royer, Judith Staerk, Marcel Costuleanu, Pierre J. Courtoy, Stefan N. Constantinescu   +4 more
openalex   +1 more source

Histopathological Characterization and Differential Expression of miRNAs in Male Pediatric Patients With Lichen Sclerosus

Andrology, EarlyView.
ABSTRACT Background Lichen sclerosus is a chronic, inflammatory, scarring disease of the skin that manifests mostly in the genital region. Objective We studied the histomorphological characteristics, grade, and pattern of inflammation in male pediatric patients with lichen sclerosus.
Valerie Flammang, Arndt Hartmann, Robert Stöhr, Katrin Weigelt, Carol Geppert, Frederik A. Stuebs, Matthias W. Beckmann, Bernd Wullich, Helge Taubert, Marios Marcou, Sven Wach   +10 more
wiley   +1 more source

Driver mutations in Janus kinases in a mouse model of B-cell leukemia induced by deletion of PU.1 and Spi-B. [PDF]

Blood Adv, 2018
Batista CR, Lim M, Laramée AS, Abu-Sardanah F, Xu LS, Hossain R, Bell GI, Hess DA, DeKoter RP.   +8 more
europepmc   +1 more source

When, which and how to switch: Navigating JAK inhibitors in myelofibrosis

British Journal of Haematology, EarlyView.
Navigating choice of JAK inhibitor (JAKi) therapy for patients with myelofibrosis who are JAKi‐naïve and for those who have previously been treated with a JAKi.
Jennifer O'Sullivan, Imran Omerdeen, Bethan Psaila   +2 more
wiley   +1 more source

Regulation of Janus kinases by SOCS proteins. [PDF]

Biochem Soc Trans, 2013
Kershaw NJ, Murphy JM, Lucet IS, Nicola NA, Babon JJ.   +4 more
europepmc   +1 more source

Emodin has a cytotoxic activity against human multiple myeloma as a Janus-activated kinase 2 inhibitor [PDF]

, 2007
Akihiro Muto, Mayumi Hori, Yosuke Sasaki, Akari Saitoh, Iho Yasuda, Tadahito Maekawa, Tomoe Uchida, Keiko Asakura, Tomonori Nakazato, Toshio Kaneda, Masahiro Kizaki, Yasuo Ikeda, Tadashi Yoshida   +12 more
openalex   +1 more source