Journal of the European Academy of Dermatology and Venereology, EarlyView.
Albert Wolkerstorfer +10 more
wiley +1 more source
A JAK of two trades: beneficial or adverse effects of Janus kinase inhibition for plasma LDL-cholesterol and major adverse cardiovascular events in inflammatory bowel disease patients? [PDF]
Curr Opin LipidolMuñoz Ayala K +2 more
europepmc +1 more source
The Janus framework of the integrated stress response: from homeostasis to maladaptation. [PDF]
Life Sci AllianceAltintas DM +3 more
europepmc +1 more source
Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs) [PDF]
Bioorganic and Medicinal Chemistry Letters, 2009 A series of phenylaminopyrimidines has been identified as inhibitors of Janus kinases (JAKs). Development of this initial series led to the potent JAK2/JAK1 inhibitor CYT387 (N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-benzamide). Details of synthesis and SAR studies of these compounds are reported.
Christopher J Burns +2 more
exaly +7 more sources
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Janus kinases and their role in growth and disease
Life Sciences, 1999Janus kinases (JAK) play a crucial role in the initial steps of cytokine signaling. Each of the four members (JAK1, JAK2, JAK3, TYK2) of this non-receptor tyrosine kinase family is indispensable for the effects of distinct cytokines. Moreover, recent reports have added to our knowledge on their highly specific functions: JAK3 knockout mice and JAK3 ...
Martin Aringer, Yong-Jie Zhou
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Role of Janus Kinase Inhibitors in Therapy of Psoriasis [PDF]
Journal of Clinical Medicine, 2021 Janus kinases inhibitors are molecules that target Janus kinases—signal transducers and activators of transcription (JAK/STAT). They inhibit this intracellular signal pathway, blocking the gene transcription of crucial proinflammatory cytokines that play
Sylwia Słuczanowska-Głąbowska +2 more
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JAKs in pathology: Role of Janus kinases in hematopoietic malignancies and immunodeficiencies [PDF]
Seminars in Cell and Developmental Biology, 2008 The four mammalian Janus kinase (JAK) family members, JAK1, JAK2, JAK3 and TYK2, are non-receptor protein tyrosine kinases (PTKs) that are crucial for cytokine receptor signaling in blood formation and immune responses.
William Vainchenker +2 more
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Janus kinase-1 and Janus kinase-2 inhibitors for treating myelofibrosis
Cochrane Database of Systematic Reviews, 2015Myelofibrosis is a bone marrow disorder characterized by excessive production of reticulin and collagen fiber deposition caused by hematological and non-hematological disorders. The prognosis of myelofibrosis is poor and treatment is mainly palliative.
Arturo J, Martí-Carvajal +2 more
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Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases [PDF]
Journal of Cellular and Molecular Medicine, 2010 peer reviewedGain-of-function mutations in the genes encoding Janus kinases have been discovered in various haematologic diseases. Jaks are composed of a FERM domain, an SH2 domain, a pseudokinase domain and a kinase domain, and a complex interplay of ...
Claude Haan, Iris Behrmann
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Negative Regulation of Janus Kinases
Cell Biochemistry and Biophysics, 2001The precise regulation of both the magnitude and the duration of Janus kinase (JAK) catalytic activity is essential for the cytokine orchestration of many biological processes, and the dysregulation of JAK activity has pathological implications.
R J, Duhé, L H, Wang, W L, Farrar
openaire +2 more sources