Results 1 to 10 of about 627,119 (126)

Effects of a novel acetaminophen analog on cardiorespiratory compensatory responses and survival in a male rat model of traumatic hemorrhage

Physiological Reports
When pain is associated with traumatic hemorrhage, medics must be concerned about secondary effects of analgesics on cardiorespiratory systems. A novel analog of acetaminophen, D‐112, was developed to circumvent liver toxicity and improve analgesic ...
Miryam M. Pando, Kathy L. Ryan, Mariam L. Calderon, Cassandra M. Rodriguez, Brian S. Connor, Samantha L. Perez, Kevin D. Bunker, Chad D. Hopkins, Harold G. Klemcke, Lonnie E. Grantham 2nd, Carmen Hinojosa‐Laborde   +10 more
doaj   +2 more sources

Comprehensive single-shot biophysical cytometry using simultaneous quantitative phase imaging and Brillouin spectroscopy

Scientific Reports, 2022
Single-cell analysis, or cytometry, is a ubiquitous tool in the biomedical sciences. Whereas most cytometers use fluorescent probes to ascertain the presence or absence of targeted molecules, biophysical parameters such as the cell density, refractive ...
Zachary A. Steelman, Zachary N. Coker, Anna Sedelnikova, Mark A. Keppler, Allen S. Kiester, Maria A. Troyanova-Wood, Bennett L. Ibey, Joel N. Bixler   +7 more
doaj   +1 more source

Early identification of sepsis in burn patients using compensatory reserve measurement: A prospective case series study

Burns Open, 2022
Background: Early identification of sepsis can be lifesaving, but current diagnostic approaches rely on standard vital signs and biochemistry analyses that delay recognition.
Victor A. Convertino, Amanda R. Wagner, Kevin S. Akers, Christopher A. VanFosson, Leopoldo C. Cancio   +4 more
doaj   +1 more source

Clearance of blood stream infections in patients receiving extracorporeal membrane oxygenation: a retrospective single-center cohort study

BMC Infectious Diseases, 2023
Background There are limited data on the treatment of blood stream infections (BSIs) in patients receiving extracorporeal membrane oxygenation (ECMO). Current guidance recommends documenting clearance only in fungal and Gram-positive BSIs.
Stone A. Frankford, Michal J. Sobieszczyk, Ana E. Markelz, Joseph E. Marcus   +3 more
doaj   +1 more source

Changes in the excitability of primary hippocampal neurons following exposure to 3.0 GHz radiofrequency electromagnetic fields

Scientific Reports, 2022
Exposures to radiofrequency electromagnetic fields (RF-EMFs, 100 kHz to 6 GHz) have been associated with both positive and negative effects on cognitive behavior. To elucidate the mechanism of RF-EMF interaction, a few studies have examined its impact on
Ibtissam Echchgadda, Jody C. Cantu, Gleb P. Tolstykh, Joseph W. Butterworth, Jason A. Payne, Bennett L. Ibey   +5 more
doaj   +1 more source

Effects of hemodilution on coagulation function during prolonged hypotensive resuscitation in a porcine model of severe hemorrhagic shock

Trauma Surgery & Acute Care Open, 2023
Background Although hemorrhage remains the leading cause of survivable death in casualties, modern conflicts are becoming more austere limiting available resources to include resuscitation products.
Clifford G Morgan, Leslie E Neidert, Emily N Hathaway, Sylvain Cardin, Jacob J Glaser, Peter J Hemond, Michael M Tiller   +6 more
doaj   +1 more source

Validation of the age-adjusted shock index for pediatric casualties in Iraq and Afghanistan

Military Medical Research, 2020
Background Pediatric casualties account for a notable proportion of encounters in the deployed setting based on the humanitarian medical care mission.
Camaren M. Cuenca, Matthew A. Borgman, Michael D. April, Andrew D. Fisher, Steven G. Schauer   +4 more
doaj   +1 more source

ASCs derived from burn patients are more prone to increased oxidative metabolism and reactive oxygen species upon passaging

Stem Cell Research & Therapy, 2021
Background Patients with severe burn injury (over 20% of the total body surface area) experience profound hypermetabolism which significantly prolongs wound healing.
David M. Burmeister, Grace Chu-Yuan Chu, Tony Chao, Tiffany C. Heard, Belinda I. Gómez, Linda E. Sousse, Shanmugasundaram Natesan, Robert J. Christy   +7 more
doaj   +1 more source

Move to health-a holistic approach to the management of chronic low back pain: an intervention and implementation protocol developed for a pragmatic clinical trial

Journal of Translational Medicine, 2021
Background The prevalence of chronic pain conditions is growing. Low back pain was the primary cause of disability worldwide out of 156 conditions assessed between 1990 and 2016, according to the Global Burden of Disease Study.
Daniel I. Rhon, Julie M. Fritz, Tina A. Greenlee, Katie E. Dry, Rachel J. Mayhew, Mary C. Laugesen, Edita Dragusin, Deydre S. Teyhen   +7 more
doaj   +1 more source

HMGB1 Inhibition to Ameliorate Organ Failure and Increase Survival in Trauma

Biomolecules, 2022
Several preclinical and clinical reports have demonstrated that levels of circulating high mobility group box 1 protein (HMGB1) are increased early after trauma and are associated with systemic inflammation and clinical outcomes.
Zhangsheng Yang, Milomir O. Simovic, Peter R. Edsall, Bin Liu, Tomas S. Cancio, Andriy I. Batchinsky, Leopoldo C. Cancio, Yansong Li   +7 more
doaj   +1 more source