JC virus detection and JC virus-specific immunity in natalizumab-treated Multiple Sclerosis patients [PDF]
Journal of Translational Medicine, 2012 Background The use of natalizumab in multiple sclerosis (MS) may favour JC virus reactivation; this phenomenon is usually asymptomatic but can, albeit rarely, evolve into frank progressive multifocal leucoencephalopathy (PML). Methods JCV-specific CD8+ T
Mancuso Roberta +8 more
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JC virus-induced progressive multifocal leukoencephalopathy in a presumably healthy patient [PDF]
BMC Neurology, 2022 Background JC virus (JCV) is common among healthy individuals and remains latent but may be reactivated under immunosuppressive conditions, resulting in progressive multifocal leukoencephalopathy (PML).
Xiang Wang +4 more
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Newly diagnosed AIDS patient with cerebellar JC virus [PDF]
IDCases, 2023 We present a case of a 57-year-old man with newly diagnosed acquired immunodeficiency syndrome (AIDS) infection who initially sought care for progressive dysarthria and gait instability.
Sergio Alvarez-Mulett +2 more
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A rare urinary JC virus reactivation after long-term therapy with rituximab
International Journal of Infectious Diseases, 2021 The possible role of JC virus in determining urinary tract involvement has only recently been recognized. The case of a man with laboratory-confirmed JC virus replication in the urine after a maintenance schedule of rituximab administered for a ...
Fabrizio Di Maida +8 more
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Adaptive mutations in the JC virus protein capsid are associated with progressive multifocal leukoencephalopathy (PML). [PDF]
PLoS Genetics, 2009 PML is a progressive and mostly fatal demyelinating disease caused by JC virus infection and destruction of infected oligodendrocytes in multiple brain foci of susceptible individuals.
Shamil R Sunyaev +3 more
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Quasispecies analysis of JC virus DNA present in urine of healthy subjects. [PDF]
PLoS ONE, 2013 JC virus is a human polyomavirus that infects the majority of people without apparent symptoms in healthy subjects and it is the causative agent of progressive multifocal leucoencephalopathy (PML), a disorder following lytic infection of oligodendrocytes
Tom Van Loy +3 more
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Human polyomavirus JC virus genome [PDF]
Journal of Virology, 1984 The complete DNA sequence of the human JC virus, which was found to consist of 5,130 nucleotide pairs, is presented. The amino acid sequence of six proteins could be deduced: the early, nonstructural proteins, large T and small t antigens; the late capsid proteins, VP1, VP2, and VP3; and the agnogene product encoded within the late leader sequence ...
R J, Frisque, G L, Bream, M T, Cannella
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Development of a Potent Stabilizer for Long-Term Storage of Foot-and-Mouth Disease Vaccine Antigens
Vaccines, 2021 A local virus isolate, O/SKR/JC/2014 (O JC), has been considered as a candidate vaccine strain in the development of a domestic foot-and-mouth disease (FMD) vaccine in Korea.
Ah-Young Kim +7 more
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Reactivation of human herpesvirus-6 in natalizumab treated multiple sclerosis patients. [PDF]
PLoS ONE, 2008 The alpha(4) integrin antagonist natalizumab was shown to be effective in patients with immune-mediated disorders but was unexpectedly associated with JC polyomavirus associated progressive multifocal leukoencephalopathy (PML) in two multiple sclerosis ...
Karen Yao +9 more
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Revista de Saúde Pública, 1977 A total of 173 sera from isolated Brazilian Indian populations, 39 from the Diauarun area, and 68 from the Alto Xingú area, respectively in the North and the South of the Xingú National Park and 66 Kren-Akorore Indians, were examined for hemagglutination
J. A. N. Candeias +3 more
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