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Progressive multifocal leukoencephalopathy (PML) is a rare disease of the central nervous system caused by opportunistic infection with JC virus. It presents in patients who are immunocompromised, and diagnosis is made by correlating clinical findings ...
Sabrina Grant +4 more
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A number of viruses can initiate central nervous system (CNS) diseases that include demyelination as a major feature of neuropathology. In humans, the most prominent demyelinating diseases are progressive multifocal leukoencephalopathy, caused by JC ...
Fazakerley, John K, Walker, Robert
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JC and BK polyomavirus-like particles as targets of innate and adaptive humoral immunity [PDF]
JC polyomavirus (JCPyV) and BK polyomavirus (BKPyV) were identified as the first of now more than 12 human polyomaviruses (HPyVs). The average JCPyV and BKPyV seroprevalence rates in adults are 70% and 90%, respectively. After asymptomatic infection both
Kardas, Piotr
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Progressive multifocal leukoencephalopathy: new concepts
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the CNS caused by reactivation of JC virus (JCV) in a setting of cellular immunosuppression.
Marco A. Lima
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JC polyoma virus and kidney disease [PDF]
To the Editor: In a recent article, Divers et al.1 describe the interaction between apolipoprotein L1 (APOL1) genotypes and JC viruria, and their relationship with nondiabetic nephropathy in African Americans. The authors found that in African Americans with two APOL1 risk alleles, the prevalence of kidney disease was lower for those with JC viruria ...
Ana P, Rossi +2 more
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Human polyomavirus JC virus genome [PDF]
The complete DNA sequence of the human JC virus, which was found to consist of 5,130 nucleotide pairs, is presented. The amino acid sequence of six proteins could be deduced: the early, nonstructural proteins, large T and small t antigens; the late capsid proteins, VP1, VP2, and VP3; and the agnogene product encoded within the late leader sequence ...
R J, Frisque, G L, Bream, M T, Cannella
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JC Virus Agnoprotein Colocalizes with Tubulin [PDF]
The human polyomavirus JC (JCV) encodes an agnoprotein that consists of 71 amino acid residues, with a molecular weight of approximately 8 kDa, from the late protein coding region. The agnoprotein of JCV shares 50% to 60% homology with those of simian virus 40 (SV40) and BK virus (BKV), and the carboxyl-terminal region of JCV agnoprotein is relatively ...
Shuichi, Endo +6 more
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COULD JC VIRUS PROVOKE METASTASIS IN COLON CANCER? [PDF]
AIM: to evaluate the prevalence of John Cunningham Virus (JC virus) in a small cohort of patients with colon cancer and to assess its presence in hepatic metastasis.METHOD: Neneteen consecutive patients with histologically diagnosed colon cancer were ...
Orlando, A +12 more
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In vitro and in vivo characterization of the cytomegalovirus and polyomavirus BK specific immune response [PDF]
During my PhD thesis several aspects of the interaction of Cytomegalovirus and Polyomavirus BK with the host’s immune system were examined (see list of publications).
Egli, Adrian
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Foot-and-mouth disease (FMD) is a fatal contagious viral disease that affects cloven-hoofed animals and causes severe economic damage at the national level.
Seong Yun Hwang +6 more
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