Results 11 to 20 of about 1,276,875 (301)

JC virus detection and JC virus-specific immunity in natalizumab-treated Multiple Sclerosis patients [PDF]

Journal of Translational Medicine, 2012
Background The use of natalizumab in multiple sclerosis (MS) may favour JC virus reactivation; this phenomenon is usually asymptomatic but can, albeit rarely, evolve into frank progressive multifocal leucoencephalopathy (PML). Methods JCV-specific CD8+ T
Mancuso Roberta, Saresella Marina, Hernis Ambra, Marventano Ivana, Ricci Cristian, Agostini Simone, Rovaris Marco, Caputo Domenico, Clerici Mario   +8 more
doaj   +4 more sources

Assessment of JC Polyoma Virus in Colon Neoplasms

Diseases of the Colon & Rectum, 2005
Research data have recently emphasized an intriguing association of JC polyoma virus with colon carcinogenesis. Tumorigenicity of JC virus is attributed to the T-antigen of its Mad-1 variant. Controversy arose when another research group did not confirm this association.
Theodoropoulos, G, Panoussopoulos, D, Papaconstantinou, I, Gazouli, M, Perdiki, M, Bramis, J, Lazaris, AC   +6 more
core   +5 more sources

JC Virus-Related Retinopathy.

JAMA Ophthalmol
ImportanceReactivation of the JC polyomavirus in individuals with impaired immunity is most commonly associated with progressive multifocal leukoencephalopathy. We report a case of polyomavirus-related retinopathy, representing a potentially novel manifestation of JC polyomavirus infection.ObjectiveTo describe a patient with common variable ...
Varenne F, Siegfried-Vergnon A, Lhomme S, Treiner E, Pignolet B, Joly M, Bonneville F, Gandia P, Rodriguez C, Cortese I, Soler V, Martin-Blondel G.   +11 more
europepmc   +5 more sources

The Pacific lineage (2E) of JC polyomavirus is prevalent in Sumba Island, Eastern Indonesia [PDF]

, 2008
Recent studies have identified a Pacific lineage (2E) of JC polyomavirus (also designated as JC virus or JCV) that occurs in both Island Southeast Asia and Oceania, but not in mainland Asia.
Nakazawa, Minato, Soemantri, Augustinus, Shimizu, Hana, Ohtsuka, Ryutaro, Shan, Zhong, Kitamura, Tadaichi, Shibuya, Ayako, Ishida, Takafumi, Yogo, Yoshiaki, Sekiyama, Makiko, Takasaka, Tomokazu, Ikegaya, Hiroshi   +11 more
core   +2 more sources

Oligosaccharides as Receptors for JC Virus [PDF]

Journal of Virology, 2002
ABSTRACT JC virus (JCV) belongs to the polyomavirus family of double-stranded DNA viruses and in humans causes a demyelinating disease of the central nervous system, progressive multifocal leukoencephalopathy. Its hemagglutination activity and entry into host cells have been reported to depend on an N-linked glycoprotein containing sialic ...
Rika, Komagome, Hirofumi, Sawa, Takashi, Suzuki, Yasuo, Suzuki, Shinya, Tanaka, Walter J, Atwood, Kazuo, Nagashima   +6 more
openaire   +2 more sources

JC Virus Infection of the Brain [PDF]

American Journal of Neuroradiology, 2010
Since its initial description, there have been significant changes in the epidemiology, pathogenesis, and clinical and imaging manifestations of JCV infection of brain. The most common clinical manifestation is PML. Other recently described CNS manifestations are JCE, JCVGCN, and JCM.
A K, Bag, J K, Curé, P R, Chapman, G H, Roberson, R, Shah   +4 more
openaire   +2 more sources

JC Virus: An oncogenic virus in animals and humans? [PDF]

Seminars in Cancer Biology, 2009
JC virus (JCV) is a human polyomavirus of the Polyomaviridae family, which also includes BK virus and simian vacuolating virus 40 (SV40). JC virus was first isolated in 1971 from the brain of a patient with Progressive Multifocal Leukoencephalopathy (PML). Like other polyomaviruses, JCV has a restricted host range. The virus infects the majority of the
Melissa S, Maginnis, Walter J, Atwood
openaire   +2 more sources

JC virus evolution and its association with human populations [PDF]

, 2006
The ubiquitous human polyomavirus JC (JCV) is a small double-stranded DNA virus that establishes a persistent infection, and it is often transmitted from parents to children.
Edward C. Holmes, Andrew Rambaut, Shackelton, Laura A., Rambaut, Andrew, Oliver G. Pybus, Laura A. Shackelton, Pybus, Oliver G., Holmes, Edward C.   +7 more
core   +1 more source

Brain tumors of owl monkeys inoculated with JC virus contain the JC virus genome [PDF]

Journal of Virology, 1984
The DNA from astrocytomas that developed in adult owl monkeys 16 to 36 months after intracranial inoculation with JC virus (JCV) was examined for the presence of the JCV genome by hybridization to cloned JCV DNA. The JCV genome was found to be integrated into the cellular DNA in all tumors examined.
N R, Miller, P E, McKeever, W, London, B L, Padgett, D L, Walker, W C, Wallen   +5 more
openaire   +2 more sources

Virus demyelination [PDF]

, 2003
A number of viruses can initiate central nervous system (CNS) diseases that include demyelination as a major feature of neuropathology. In humans, the most prominent demyelinating diseases are progressive multifocal leukoencephalopathy, caused by JC ...
Fazakerley, John K, Walker, Robert
core   +1 more source