Progressive multifocal leukoencephalopathy in the clinical practice of a neurologist. Case report [PDF]
Consilium MedicumProgressive multifocal leukoencephalopathy (PML) is an opportunistic infection with severe brain damage caused by the JC-virus, against the background of immunosuppressive conditions.
Yuliana A. Belova, Sergey V. Kotov
doaj +1 more source
The agnoprotein of polyomavirus JC is released by infected cells: Evidence for Its cellular uptake by uninfected neighboring cells [PDF]
, 2014 Poliomavirus JC replicates in glial cells in the brain, and causes the fatal demyelinating disease, progressive multifocal leukoencephalopathy (PML).
De Simone, Francesca Isabella +4 more
core +1 more source
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Roles of intrinsic anisotropy and pi-band pairbreaking effects on critical currents in tilted c-axis MgB2 films probed by magneto-optical and transport measurements [PDF]
Phys. Rev. B 90, 214509 (2014), 2014 Investigations of MgB2 and Fe-based superconductors in recent years have revealed many unusual effects of multiband superconductivity but manifestations of anisotropic multiband effects in the critical current density Jc have not been addressed experimentally, mostly because of the difficulties to measure Jc along the c-axis.
arxiv +1 more source
Neurology International, 2013 The JC polyoma viral coat protein VP1 was analyzed for amino acid sequences homologies to the IDSP sequence which mediates binding of VLA-4 (integrin alpha 4) to vascular cell adhesion molecule 1.
Michael Andrew Meyer
doaj +1 more source
ViroFind: A novel target-enrichment deep-sequencing platform reveals a complex JC virus population in the brain of PML patients. [PDF]
PLoS ONE, 2018 Deep nucleotide sequencing enables the unbiased, broad-spectrum detection of viruses in clinical samples without requiring an a priori hypothesis for the source of infection.
Spyros Chalkias +9 more
doaj +1 more source
Central role of JC virus-specific CD4+ lymphocytes in progressive multi-focal leucoencephalopathy-immune reconstitution inflammatory syndrome [PDF]
, 2017 Progressive multi-focal leucoencephalopathy and progressive multi-focal leucoencephalopathy-immune reconstitution inflammatory syndrome are caused by infection of the central nervous system with the JC polyoma virus.
Aly, Lilian +15 more
core
CINs of the cytoplasm: dissecting dsRNA signaling in chromosomal instability
Molecular Oncology, EarlyView.Micronuclei, formed during cell division in chromosomal instability settings, rupture and lead to the accumulation of immunogenic double‐stranded RNA in the cytoplasm, activating MAVS‐dependent interferon signaling and innate antitumor immunity.
Aglaia Skolariki +2 more
wiley +1 more source
A counterexample to a group completion conjecture of JC Moore [PDF]
Algebr. Geom. Topol. 2 (2002) 33-35, 2002 We provide a simple explicit counterexample to a group completion conjecture for simplicial monoids attributed to JC Moore.
arxiv +1 more source
JC Polyomavirus Nephropathy: A Rare Complication Late after Kidney Transplantation
Case Reports in Nephrology and DialysisIntroduction: JC-polyomavirus-associated nephropathy (JC-PVAN) is a rare cause of allograft dysfunction with only a few cases described in the literature.
Jennifer Scotti Gerber +4 more
doaj +1 more source