Results 51 to 60 of about 1,276,875 (301)

Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy [PDF]

, 2006
Background: Progressive multifocal leukoencephalopathy (PML) was reported to have developed in three patients treated with natalizumab. We conducted an evaluation to determine whether PML had developed in any other treated patients.
Major, E.O., Clifford, D.B., Habil, M., Fischer, S., Barkhof, F., Yousry, T.A., Hou, J., Radue, E.-W., Ryschkewitsch, C., Mueller-Lenke, N., Jäger, H.R., Sanchez, E., Curfman, B., Miszkiel, K., Fahle, G.   +14 more
core  

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

A fulminant case of JC virus encephalopathy supporting a novel syndrome associated with JC virus infection of cortical neurons [PDF]

Journal of Health and Social Sciences, 2016
The JC virus ( JCV) is well known for causing progressive multifocal leukoencephalopathy (PML), a potentially fatal, demyelinating disease of the central nervous system (CNS).
Matteo Ciocca, Marta Pirovano, Monica Lodi, Antonino Romeo, Vincenza Fetoni   +4 more
doaj   +1 more source

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Progressive multifocal leukoencephalopathy in the clinical practice of a neurologist. Case report [PDF]

Consilium Medicum
Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection with severe brain damage caused by the JC-virus, against the background of immunosuppressive conditions.
Yuliana A. Belova, Sergey V. Kotov
doaj   +1 more source

Progressive multifocal leukoencephalopathy and immune reconstitution inflammatory syndrome in seven patients with sarcoidosis: a critical discussion of treatment and prognosis

Therapeutic Advances in Neurological Disorders, 2021
Progressive multifocal leukoencephalopathy (PML) is a subacute brain infection by the opportunistic John Cunningham (JC) virus. Herein, we describe seven patients with PML, lymphopenia, and sarcoidosis, in three of whom PML was the first manifestation of
Maike F. Dohrn, Gisa Ellrichmann, Rastislav Pjontek, Carsten Lukas, Jens Panse, Ralf Gold, Jörg B. Schulz, Burkhard Gess, Simone C. Tauber   +8 more
doaj   +1 more source

VALIDAÇÃO DO MÉTODO PCR EM TEMPO REAL PARA DIAGNÓSTICO DE CITOMEGALOVÍRUS E DOS POLIOMAVÍRUS BK E JC EM AMOSTRAS DE PACIENTES TRANSPLANTADOS RENAIS

Hematology, Transfusion and Cell Therapy, 2023
Introdução e objetivo: Os poliomavírus e citomegalovírus são vírus ubíquos na população que permanecem latentes em vários tecidos de indivíduos portadores.
MLMV Corgozinho, S Vilaça, A França, AGG Oliveira, LV Alves, JKPD Reis, BEF Mota, APL Mota   +7 more
doaj   +1 more source

Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment

Advanced Science, EarlyView.
Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu, Jiaxuan Chen, Abdechakour Elkihel, Wenjun Lan, Nicolas Fraunhoffer, Dandan Zhu, Baoping Lian, Christina Galanakou, Zhancun Bian, Xi Liu, Odile Gayet, Loic Moubri, Julie Aglietti Roques, Vikash Reebye, Nagy Habib, Xiaoxuan Liu, Nelson Dusetti, Juan Lucio Iovanna, Ling Peng   +18 more
wiley   +1 more source

Amino acid sequences mediating vascular cell adhesion molecule 1 binding to integrin alpha 4: homologous DSP sequence found for JC polyoma VP1 coat protein

Neurology International, 2013
The JC polyoma viral coat protein VP1 was analyzed for amino acid sequences homologies to the IDSP sequence which mediates binding of VLA-4 (integrin alpha 4) to vascular cell adhesion molecule 1.
Michael Andrew Meyer
doaj   +1 more source

JC Virus Infection: A Clinical Conundrum

Journal of the College of Physicians and Surgeons Pakistan, 2019
John Cunningham virus (JCV), a member of polyomaviridae family, has been described as a cause of the progressive multifocal leukoencephalopathy (PML). It is a potentially fatal, disabling demyelinating infection of the brain occurring mostly in the setting of immunosuppression.
Hajra, Farooq, Saifullah Khan, Niazi, Misbah, Noor, Eijaz, Ghani   +3 more
openaire   +2 more sources