Results 61 to 70 of about 71,442 (302)

A fulminant case of JC virus encephalopathy supporting a novel syndrome associated with JC virus infection of cortical neurons [PDF]

Journal of Health and Social Sciences, 2016
The JC virus ( JCV) is well known for causing progressive multifocal leukoencephalopathy (PML), a potentially fatal, demyelinating disease of the central nervous system (CNS).
Matteo Ciocca, Marta Pirovano, Monica Lodi, Antonino Romeo, Vincenza Fetoni   +4 more
doaj   +1 more source

VALIDAÇÃO DO MÉTODO PCR EM TEMPO REAL PARA DIAGNÓSTICO DE CITOMEGALOVÍRUS E DOS POLIOMAVÍRUS BK E JC EM AMOSTRAS DE PACIENTES TRANSPLANTADOS RENAIS

Hematology, Transfusion and Cell Therapy, 2023
Introdução e objetivo: Os poliomavírus e citomegalovírus são vírus ubíquos na população que permanecem latentes em vários tecidos de indivíduos portadores.
MLMV Corgozinho, S Vilaça, A França, AGG Oliveira, LV Alves, JKPD Reis, BEF Mota, APL Mota   +7 more
doaj   +1 more source

RNA interference targets arbovirus replication in Culicoides cells [PDF]

, 2013
Arboviruses are transmitted to vertebrate hosts by biting arthropod vectors such as mosquitoes, ticks and midges. These viruses replicate in both arthropods and vertebrates and are thus exposed to different antiviral responses in these organisms.
Varela, Mariana, Esther Schnettler, Ratinier, Maxime, Shaw, Andrew, Palmarini, Massimo, Kohl, Alain, Mariana Varela, Mick Watson, Elliott, Richard M., Alain Kohl, Maxime Ratinier, McFarlane, Melanie, Shaw, Andrew E., Elliott, Richard, Richard M, Massimo Palmarini, Schnettler, Esther, E. Shaw, Watson, Mick, A Alain Kohla, Melanie Mcfarlane   +20 more
core   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Amino acid sequences mediating vascular cell adhesion molecule 1 binding to integrin alpha 4: homologous DSP sequence found for JC polyoma VP1 coat protein

Neurology International, 2013
The JC polyoma viral coat protein VP1 was analyzed for amino acid sequences homologies to the IDSP sequence which mediates binding of VLA-4 (integrin alpha 4) to vascular cell adhesion molecule 1.
Michael Andrew Meyer
doaj   +1 more source

Progressive multifocal leukoencephalopathy and immune reconstitution inflammatory syndrome in seven patients with sarcoidosis: a critical discussion of treatment and prognosis

Therapeutic Advances in Neurological Disorders, 2021
Progressive multifocal leukoencephalopathy (PML) is a subacute brain infection by the opportunistic John Cunningham (JC) virus. Herein, we describe seven patients with PML, lymphopenia, and sarcoidosis, in three of whom PML was the first manifestation of
Maike F. Dohrn, Gisa Ellrichmann, Rastislav Pjontek, Carsten Lukas, Jens Panse, Ralf Gold, Jörg B. Schulz, Burkhard Gess, Simone C. Tauber   +8 more
doaj   +1 more source

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

Glial cell-specific regulation of the JC virus early promoter by histone deacetylase inhibitors

, 2018
The human polyomavirus JC virus is the etiologic agent of the fatal disease demyelinating progressive multifocal leukoencephalopathy. Although multiple transcription factors have been shown to interact with the JC virus promoter and regulate ...
김희선
core   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Progressive multifocal leukoencephalopathy in the clinical practice of a neurologist. Case report [PDF]

Consilium Medicum
Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection with severe brain damage caused by the JC-virus, against the background of immunosuppressive conditions.
Yuliana A. Belova, Sergey V. Kotov
doaj   +1 more source