Results 271 to 280 of about 120,648 (332)

St. John’s Wort Extract Increases Pgp Expression in the Brain but Not in the Small Intestine or the Liver of Wistar Rats

open access: yesPharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.
ABSTRACT St John's Wort (SJW), commonly used to treat mild depression, is known to pose a risk of drug–herb interactions through hyperforin‐mediated activation of the pregnane X receptor (PXR). This induces transcription and expression of PXR target genes, including the efflux transporter P‐glycoprotein (Pgp).
Valerio Taggi   +3 more
wiley   +1 more source

Biopsy‐Sparing Diagnosis of Coeliac Disease Based on Endomysial Antibody Testing and Clinical Risk Assessment

open access: yesAlimentary Pharmacology &Therapeutics, Volume 61, Issue 11, Page 1794-1804, June 2025.
We developed and prospectively validated a non‐invasive diagnostic strategy based on age at presentation and alarm symptoms, enabling safe biopsy‐free diagnosis of coeliac disease using endomysial antibodies. Younger adults (age < 45 years) without alarm symptoms can be diagnosed non‐invasively based on EmA, while older patients (age ≥ 45 years) with ...
Stiliano Maimaris   +13 more
wiley   +1 more source

Antibiotic‐induced decrease of bacterial load in guinea pig intestine reduces α2‐adrenoceptor expression and activity in peristaltic motor inhibition

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 12, Page 2642-2661, June 2025.
Background and Purpose The use of analgosedatives in critically ill patients carries the risk of impairing gastrointestinal (GI) propulsion and could thereby lead to sepsis. The gut microbiota can influence GI motility, but whether GI microbial dysbiosis modifies GI peristalsis impairment by analgosedative drugs has not yet been analysed. This question
Aitak Farzi   +5 more
wiley   +1 more source

Primary aorto-enteric fistula diagnosed by double-balloon endoscopy. [PDF]

open access: yesDEN Open
Yamamoto M   +9 more
europepmc   +1 more source

Understanding the Impact of Ostomy Dejecta Constituents on Peristomal Skin Health and Models for Its Characterisation

open access: yesInternational Wound Journal, Volume 22, Issue 6, June 2025.
ABSTRACT An ostomy, or stoma, is a surgically created percutaneous aperture from a hollow organ (e.g., small intestine) to the body's surface. Physicians may recommend an ostomy as a temporary or permanent solution to a range of disorders of the gastrointestinal tract, with up to 130 000 ostomies performed annually in the United States.
Mirella A. Ejiugwo   +5 more
wiley   +1 more source

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