Results 11 to 20 of about 2,720 (170)

Inhibition of NHE1 Overcomes Temozolomide-Resistance in Glioblastoma via ROS-AKT/ERK Axis-Mediated Autophagy Suppression. [PDF]

J Biochem Mol Toxicol
NHE1 inhibition via HOE‐642 suppresses autophagy through the ROS‐AKT/ERK axis, reversing temozolomide resistance in glioblastoma by disrupting the autophagy‐apoptosis balance and enhancing TMZ sensitivity in vitro and in vivo. ABSTRACT Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with temozolomide (TMZ) resistance being a ...
Li D, Li Y, Zheng X, Wang Z, Wang Y, Zhang J, Guo J, Wang L, Li J, Liu Y, Li Y.   +10 more
europepmc   +2 more sources

Morphological and molecular characterization of Geocenamus persici n. sp. (Nematoda: Merliniinae) from China

, 2022
Zhang, Chenying, Munawar, Maria, Castillo, Pablo, Han, Shaojie, Zheng, Jingwu (2022): Morphological and molecular characterization of Geocenamus persici n. sp. (Nematoda: Merliniinae) from China.
Zheng, Jingwu, Munawar, Maria, Castillo, Pablo, Han, Shaojie, Zhang, Chenying   +4 more
core   +1 more source

Exosomal circ‐AHCY promotes glioblastoma cell growth via Wnt/β‐catenin signaling pathway

Annals of Clinical and Translational Neurology, Volume 10, Issue 6, Page 865-878, June 2023., 2023
Abstract Background Glioblastoma (GBM) is the most aggressive brain tumor. Reportedly, circular RNAs (circRNAs) participate in regulation of the development and progression of diverse cancers, including GBM. Methods Dysregulated circRNAs in GBM tissues were screened out from GEO database.
Yuhui Li, Xuan Zheng, Jiangong Wang, Mingyang Sun, Dan Li, Zhuo Wang, Jingwu Li, Yufeng Li, Yongliang Liu   +8 more
wiley   +1 more source

Basic fibroblast growth factor‐loaded methacrylate gelatin hydrogel microspheres for spinal nerve regeneration

Smart Medicine, Volume 2, Issue 2, May 2023., 2023
The carboxylated methacrylate gelatin (GelMA) microspheres were combined with the amino group of basic fibroblast growth factor (bFGF) to obtain bFGF‐GelMA microspheres. bFGF‐GelMA microspheres were injected into the site of spinal cord injury, and bFGF was released slowly.
Xiaoyan Chen, Lei Ren, Hui Zhang, Yangnan Hu, Menghui Liao, Yingbo Shen, Kaichen Wang, Jiaying Cai, Hong Cheng, Jiamin Guo, Yanru Qi, Hao Wei, Xiaokun Li, Luoran Shang, Jian Xiao, Jingwu Sun, Renjie Chai   +16 more
wiley   +1 more source

Endothelial Glycocalyx Injury in SARS‐CoV‐2 Infection: Molecular Mechanisms and Potential Targeted Therapy

Mediators of Inflammation, Volume 2023, Issue 1, 2023., 2023
This review aims at summarizing state‐of‐the‐art knowledge on glycocalyx and SARS‐CoV‐2. The endothelial glycocalyx is a dynamic grid overlying the surface of the endothelial cell (EC) lumen and consists of membrane‐bound proteoglycans and glycoproteins.
Bingxuan Lv, Shengshi Huang, Hong Huang, Na Niu, Ju Liu, Mohammad Shadab   +5 more
wiley   +1 more source

Inhibition of MEK signaling prevents SARS‐CoV2‐induced lung damage and improves the survival of infected mice

Journal of Medical Virology, Volume 94, Issue 12, Page 6097-6102, December 2022., 2022
Abstract Coronavirus disease 2019 (COVID‐19) is the illness caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Over 500 million confirmed cases of COVID‐19 have been recorded, with six million deaths. Thus, reducing the COVID‐19‐related medical burden is an unmet need.
Jingwu Xie, Michael J. Klemsz, Melissa A. Kacena, George Sandusky, Xiaoli Zhang, Mark H. Kaplan   +5 more
wiley   +1 more source

Two‐Wave Variable Nanotheranostic Agents for Dual‐Mode Imaging‐Guided Photo‐Induced Triple‐Therapy for Cancer

Advanced Science, Volume 9, Issue 27, September 23, 2022., 2022
A two‐wave variable nanotheranostics strategy is proposed to enhance magnetic resonance imaging/near‐infrared fluorescence imaging dual‐mode imaging‐guided photo‐induced triple‐therapy for cancer. The nanotheranostic agents SIA‐αTSLs possess the ability of precise localization and light‐controlled drug release, which is beneficial to improve chemo ...
Xiao Sang, Tong Gao, Xiaoqing Liu, Yelong Shen, Lili Chang, Shunli Fu, Han Yang, Huizhen Yang, Weiwei Mu, Shuang Liang, Zipeng Zhang, Na Zhang, Yongjun Liu   +12 more
wiley   +1 more source

Plin5, a New Target in Diabetic Cardiomyopathy

Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
Abnormal lipid accumulation is commonly observed in diabetic cardiomyopathy (DC), which can create a lipotoxic microenvironment and damage cardiomyocytes. Lipid toxicity is an important pathogenic factor due to abnormal lipid accumulation in DC. As a lipid droplet (LD) decomposition barrier, Plin5 can protect LDs from lipase decomposition and regulate ...
Xiangning Cui, Jingwu Wang, Yang Zhang, Jianliang Wei, Yan Wang, Jos L. Quiles   +5 more
wiley   +1 more source

The Molecular Mechanisms of Defective Copper Metabolism in Diabetic Cardiomyopathy

Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
Copper is an essential trace metal element that significantly affects human physiology and pathology by regulating various important biological processes, including mitochondrial oxidative phosphorylation, connective tissue crosslinking, and antioxidant defense.
Xiangning Cui, Yan Wang, Han Liu, Mengjun Shi, Jingwu Wang, Yifei Wang, Sachchida Nand Rai   +6 more
wiley   +1 more source

Nitrooleic Acid Attenuates Lipid Metabolic Disorders and Liver Steatosis in DOCA-Salt Hypertensive Mice

PPAR Research, 2015
Nitrooleic acid (OA-NO2) is endogenous ligands for peroxisome proliferator-activated receptors. The present study was aimed at investigating the beneficial effects of OA-NO2 on the lipid metabolism and liver steatosis in deoxycorticosterone acetate ...
Haiping Wang, Jing Sun, Zhanjun Jia, Tianxin Yang, Liang Xu, Bing Zhao, Kezhou Yu, Rong Wang   +7 more
doaj   +1 more source