Results 11 to 20 of about 1,849 (130)

Endothelial Glycocalyx Injury in SARS‐CoV‐2 Infection: Molecular Mechanisms and Potential Targeted Therapy

open access: yesMediators of Inflammation, Volume 2023, Issue 1, 2023., 2023
This review aims at summarizing state‐of‐the‐art knowledge on glycocalyx and SARS‐CoV‐2. The endothelial glycocalyx is a dynamic grid overlying the surface of the endothelial cell (EC) lumen and consists of membrane‐bound proteoglycans and glycoproteins.
Bingxuan Lv   +5 more
wiley   +1 more source

Inhibition of MEK signaling prevents SARS‐CoV2‐induced lung damage and improves the survival of infected mice

open access: yesJournal of Medical Virology, Volume 94, Issue 12, Page 6097-6102, December 2022., 2022
Abstract Coronavirus disease 2019 (COVID‐19) is the illness caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Over 500 million confirmed cases of COVID‐19 have been recorded, with six million deaths. Thus, reducing the COVID‐19‐related medical burden is an unmet need.
Jingwu Xie   +5 more
wiley   +1 more source

Two‐Wave Variable Nanotheranostic Agents for Dual‐Mode Imaging‐Guided Photo‐Induced Triple‐Therapy for Cancer

open access: yesAdvanced Science, Volume 9, Issue 27, September 23, 2022., 2022
A two‐wave variable nanotheranostics strategy is proposed to enhance magnetic resonance imaging/near‐infrared fluorescence imaging dual‐mode imaging‐guided photo‐induced triple‐therapy for cancer. The nanotheranostic agents SIA‐αTSLs possess the ability of precise localization and light‐controlled drug release, which is beneficial to improve chemo ...
Xiao Sang   +12 more
wiley   +1 more source

Plin5, a New Target in Diabetic Cardiomyopathy

open access: yesOxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
Abnormal lipid accumulation is commonly observed in diabetic cardiomyopathy (DC), which can create a lipotoxic microenvironment and damage cardiomyocytes. Lipid toxicity is an important pathogenic factor due to abnormal lipid accumulation in DC. As a lipid droplet (LD) decomposition barrier, Plin5 can protect LDs from lipase decomposition and regulate ...
Xiangning Cui   +5 more
wiley   +1 more source

The Molecular Mechanisms of Defective Copper Metabolism in Diabetic Cardiomyopathy

open access: yesOxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
Copper is an essential trace metal element that significantly affects human physiology and pathology by regulating various important biological processes, including mitochondrial oxidative phosphorylation, connective tissue crosslinking, and antioxidant defense.
Xiangning Cui   +6 more
wiley   +1 more source

Pancancer Analysis of Revealed TDO2 as a Biomarker of Prognosis and Immunotherapy

open access: yesDisease Markers, Volume 2022, Issue 1, 2022., 2022
Background. Tryptophan 2,3‐dioxygenase (TDO) encoded by TDO2, a rate‐limiting enzyme in the kynurenine pathway, catabolizes tryptophan to kynurenine, evades immune surveillance, and promotes tumor growth. Although accumulating evidence suggests a crucial role of TDO2 during tumor formation and development, systematic evaluation of TDO2 across human ...
Jing Cui   +7 more
wiley   +1 more source

Mitochondrial Dysfunction Pathway Alterations Offer Potential Biomarkers and Therapeutic Targets for Ovarian Cancer

open access: yesOxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
The mitochondrion is a very versatile organelle that participates in some important cancer‐associated biological processes, including energy metabolism, oxidative stress, mitochondrial DNA (mtDNA) mutation, cell apoptosis, mitochondria‐nuclear communication, dynamics, autophagy, calcium overload, immunity, and drug resistance in ovarian cancer ...
Liang Shen   +2 more
wiley   +1 more source

Governing Cross-Border Data Flows: International Trade Agreements and Their Limits

open access: yesLaws, 2022
In modern international competition and cooperation, digital trade rules centered on the cross-border flow of data have become a competitive advantage for countries.
Yik-Chan Chin, Jingwu Zhao
doaj   +1 more source

Analysis of Predictors for Lymph Node Metastasis in Patients with Superficial Esophageal Carcinoma

open access: yesGastroenterology Research and Practice, 2016
In order to predict related risk factors for lymph node metastasis (LNM) in patients with superficial esophageal carcinoma (SEC) and provide reference for endoscopic minimally invasive treatment, we included a total of 93 patients with superficial ...
Ruzhen Jia   +4 more
doaj   +1 more source

Nitrooleic Acid Protects against Cisplatin Nephropathy: Role of COX-2/mPGES-1/PGE2 Cascade

open access: yesMediators of Inflammation, 2015
Nitrooleic acid (OA-NO2) is an endogenous lipid product which has novel signaling properties, particularly the activation of peroxisome proliferator-activated receptors.
Haiping Wang   +8 more
doaj   +1 more source

Home - About - Disclaimer - Privacy