Results 121 to 130 of about 161,447 (312)

Interleukin-17-induced Gene Expression in Articular Chondrocytes Is Associated with Activation of Mitogen-activated Protein Kinases and NF-κB*

Journal of Biological Chemistry, 1998
This study examines intracellular signaling events associated with the activation of chondrocytes by the cytokine interleukin-17 (IL-17). Stimulation of normal human articular chondrocytes with IL-17 induced nitric oxide (NO) production, concomitant with
Tali Shalom-Barak, J. Quach, M. Lotz
semanticscholar   +1 more source

Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn. [PDF]

, 2000
Macrophage Fcgamma receptors (FcgammaRs) mediate the uptake and destruction of antibody-coated viruses, bacteria, and parasites. We examined FcgammaR signaling and phagocytic function in bone marrow-derived macrophages from mutant mice lacking the major ...
Crowley, MT, DeFranco, AL, Finn, AJ, Fitzer-Attas, CJ, Lowell, CA, Lowry, M, Meng, F   +6 more
core  

Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation [PDF]

, 2019
The aberrant activation of hedgehog (HH) signaling is a leading cause of the development of medulloblastoma, a pediatric tumor of the cerebellum. The FDA‑approved HH inhibitor, Vismodegib, which targets the transmembrane transducer SMO, has shown limited
Agostinelli, Enzo, Antonucci, Laura, Bordone, Rosa, Caimano, Miriam, Canettieri, Gianluca, Capalbo, Carlo, Checquolo, Saula, Coni, Sonia, D'Amico, Davide, De Smaele, Enrico, Di Magno, Laura, Di Marcotullio, Lucia, Di Pastena, Fiorella, Giorgi, Alessandra, Manni, Simona, Maroder, Marella, Petroni, Marialaura, Schininà, Maria Eugenia, Serrao, Silvia Maria, Yates Iii, John R, Yurtsever, Zuleyha Nihan   +20 more
core   +1 more source

RTA‐408 Enhances Radiosensitivity and Inhibited Tumor Progression via JNK Pathway in Glioblastoma

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Glioblastoma (GBM) is an aggressive brain tumor with poor prognosis owing to its high invasiveness and resistance to therapy. RTA‐408, a synthetic triterpenoid and nuclear factor erythroid 2‐related factor 2 activator, exhibits anti‐inflammatory and anti‐cancer properties; however, its effects on GBM remain unclear. This study investigated the
Hung‐Pei Tsai, Hao Qin, Yoon Bin Chong, I‐Hsiang Chen, Shih‐Hsun Kuo, Tzu‐Ting Tseng, Ann‐Shung Lieu   +6 more
wiley   +1 more source

MAPK/ERK and JNK pathways regulate lipid synthesis and cell growth of Chlamydomonas reinhardtii under osmotic stress, respectively

Scientific Reports, 2018
Microalgae have great potential for the production of biofuels due to the ability of the organism to accumulate large quantities of storage lipids under stress conditions.
Ahreum Yang, William I. Suh, Nam Kyu Kang, Bongsoo Lee, Yong Keun Chang   +4 more
doaj   +1 more source

Targeting of p38 Mitogen-Activated Protein Kinases to MEF2 Transcription Factors

Molecular and Cellular Biology, 1999
Mitogen-activated protein (MAP) kinase-mediated signalling to the nucleus is an important event in the conversion of extracellular signals into a cellular response.
Shen-hsi Yang, Alexandros Galanis, A. Sharrocks   +2 more
semanticscholar   +1 more source

The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease [PDF]

, 2010
The dramatic recent rise in the incidence of allergic or autoimmune inflammatory diseases in the West has been proposed to reflect the lack of appropriate priming of the immune response by infectious agents such as parasitic worms during childhood ...
Al-Riyami, Al-Riyammi, Aoyama, Baev, Bashir, Bogoyevitch, Borghouts, Bowdish, Bowdish, Bradley, Brattig, Burke, Burke, Burke, Busse, Calpe, Choubey, Clutter, Cooper, Couper, Croese, Dagia, Deehan, Diaz, Dittrich, Divangahi, Elliott, Elliott, Elliott, Everts, Fabriek, Falcone, Fulkerson, Goodridge, Goodridge, Goodridge, Goodridge, Goodridge, Gu, Hamerman, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, He, Houston, Hunter, Ishibashi, Jayapal, Johnson, Kakinuma, Katschke, Kean, Khan, Kim, King, Kitagaki, Kuroki, Lai, Lai, Lamb, Lubberts, Maizels, Mansoor, Marshall, Maurer, McInnes, McInnes, Melendez, Mendoza, Mi, Mori, Moriyama, Moriyama, Moriyama, Nagel-Wolfrum, Node, Page, Polfliet, Pushparaj, Pushparaj, Rajan, Reddy, Rioja, Rogers, Satoh, Saunders, Schnoeller, Schramm, Schramm, Steinfelder, Strickland, Subramanian, Suciu-Foca, Thalhamer, Thomas, Tilstra, van Riet, Wang, Wang, WHO, Wills-Karp, Wilson, Wohlleben, Wong, Wray, Zaccone   +111 more
core   +2 more sources

Combined Effects of Puerarin and Adipose‐Derived Stem Cells on Alveolar Bone Preservation and Inflammation Control in Periodontitis Through p38MAPK Modulation

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study evaluated the effects of puerarin and adipose‐derived stem cells (ADSCs), alone or combined, on p38MAPK activity, alveolar bone preservation, and inflammatory responses in a rat periodontitis (PD) model and in vitro. ADSCs were exposed to various puerarin concentrations to assess cell proliferation, osteogenic differentiation, and ...
Ting Yang, Xu Zhang, Liang‐Fu Zhang
wiley   +1 more source

Pathogenetic role of tissue factor in graft-versus-host disease [PDF]

, 2008
Graft-versus-host disease (GVHD) is a serious complication after allogeneic stem cell transplantation, the mechanism of it is still not elucidated.
Li Quan, Li Weiming, Zhang Jian, Zou Ping   +3 more
core   +1 more source

Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway [PDF]

, 2003
Objective. Erythropoietin (EPO) is a key regulator of erythropoiesis, playing a role in both the proliferation and differentiation of erythroid cells.
Bieber, Boer, Chung, Decker, Gabrilove, Gonzalez, Goodnough, Gotoh, Haq, Jain, Jain, Jonk, Kaptein, Kirito, Kirito, Kirito, Lim, Millot, Miyazaki, Mulcahy, Ng, Schuringa, Schuringa, Schuringa, Smithgall, Socolovsky, Teglund, Tilbrook, Turkson, Watowich, Wen, Wen, Woetmann, Yokogami, Youssoufian, Yu, Zhang   +36 more
core   +1 more source