Results 121 to 130 of about 167,044 (343)

An unexpected twist to the activation of IKKβ:TAK1 primes IKKβ for activation by autophosphorylation [PDF]

, 2014
IKKβ {IκB [inhibitor of NF-κB (nuclear factor κB)] kinase β} is required to activate the transcription factor NF-κB, but how IKKβ itself is activated in vivo is still unclear.
Bain, Clark, Clark, Clark, Ea, Emmerich, Fleming, Hacker, Jiazhen Zhang, Kanayama, Kensche, Kirisako, Kristopher Clark, Lawrence, Lo, Mark W. Peggie, McCool, Nanda, Ninomiya-Tsuji, Pauls, Philip Cohen, Polley, Rahighi, Rothwarf, Sakurai, Sato, Shim, Singhirunnusorn, Toby Lawrence, Tokunaga, Wang, Woods, Wu, Xia, Yamaoka, Yang   +35 more
core   +3 more sources

The Encapsulation Strategies for Targeted Delivery of Probiotics in Preventing and Treating Colorectal Cancer: A Review

Advanced Science, EarlyView.
This work summarizes the efficacy and mechanisms of probiotics in CRC treatment, providing a comprehensive overview of various encapsulation methods such as microcapsules, hydrogels, single‐cell nanocoatings, and nanofibers for targeted probiotic delivery to inflammatory sites, with particular emphasis on the potential advantages of emerging single ...
Hao Zhong, Jin Jiang, Muhammad Hussain, Haoxuan Zhang, Ling Chen, Rongfa Guan   +5 more
wiley   +1 more source

Normal mesenteric lymph ameliorates lipopolysaccharide challenge-induced spleen injury [PDF]

Acta Cirúrgica Brasileira, 2015
PURPOSE: This study was conducted to investigate the effect of normal mesenteric lymph (NML) from mice on the spleen injury induced by lipopolysaccharide (LPS) challenge.METHODS: Mice in the LPS and LPS+NML groups received an intraperitoneal injection of
Li-min Zhang, Wen Song, Hao Cui, Li-qiang Xing, Hui-bo Du, Ying Cui, Wei-hong Chen, Zi-gang Zhao, Chun-yu Niu   +8 more
doaj   +1 more source

Mitogen-activated protein kinases and their role in radiation response.

Genes & cancer, 2013
Ionizing radiation, like a variety of other cellular stress factors, can activate or down-regulate multiple signaling pathways, leading to either increased cell death or increased cell proliferation.
A. Munshi, R. Ramesh
semanticscholar   +1 more source

Immunolocalization of dually phosphorylated MAPKs in dividing root meristem cells of Vicia faba, Pisum sativum, Lupinus luteus and Lycopersicon esculentum [PDF]

, 2015
Key message In plants, phosphorylated MAPKs display constitutive nuclear localization; however, not all studied plant species show co-localization of activated MAPKs to mitotic microtubules.
A Bessard, A Neupane, A Neupane, A Pitzschke, AK Sinha, Aneta Żabka, AP Smertenko, D Ortiz-Masia, F Kong, G Komis, G Taj, G Tena, H Nakagami, J Müller, J Schindelin, Janusz Maszewski, Joanna Bernasińska, K Kosetsu, Karolina Matczak, Konrad Winnicki, L Bögre, M Beck, M Beck, M Cargnello, M Fernandez-Pascual, M Ohori, M Ovečka, M Sasabe, M Wrzaczek, MA González Besteiro, MAPK Group, MM Horne, NS Mishra, O Šamajová, PJ Krysan, R Ulm, R Ulm, RM Perrett, T Hayashi, V Smékalová, W Ligterink, X Liu, X Qian   +42 more
core   +2 more sources

Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection

Animal Models and Experimental Medicine, EarlyView.
Quercetin regulates signaling pathways in neurodegenerative diseases, including NF‐κB, sirtuins, and PI3K/Akt. Studies show quercetin improves symptoms and pathology in neurodegenerative models. The study aims to incorporate laboratory research into practical medical treatment, focusing on quercetin's neuroprotective effects and optimal dosage ...
Md. Rezaul Islam, Md. Ibrahim Khalil Al‐Imran, Mehrukh Zehravi, Sherouk Hussein Sweilam, Mohammad Rakib Mortuza, Jeetendra Kumar Gupta, Thukani Sathanantham Shanmugarajan, Kadirvel Devi, Tanuja Tummala, Mohammed Ali Alshehri, Kalirajan Rajagopal, Mohammed Asiri, Irfan Ahmad, Talha Bin Emran   +13 more
wiley   +1 more source

Deregulated JNK signaling enhances apoptosis during hyperthermia

International Journal of Hyperthermia
Purpose c-Jun N-terminal kinases (JNKs) comprise a subfamily of mitogen-activated protein kinases (MAPKs). The JNK group is known to be activated by a variety of stimuli.
Atsushi Enomoto, Takemichi Fukasawa, Hiroshi Terunuma, Keiichi Nakagawa, Ayumi Yoshizaki, Shinichi Sato, Noriko Hosoya, Kiyoshi Miyagawa   +7 more
doaj   +1 more source

Pathway interactions between MAPKs, mTOR, PKA, and the glucocorticoid receptor in lymphoid cells

Cancer Cell International, 2007
Background Glucocorticoids are frequently used as a primary chemotherapeutic agent in many types of human lymphoid malignancies because they induce apoptosis through activation of the glucocorticoid receptor, with subsequent alteration of a complex ...
Thompson E Brad, Johnson Betty H, Garza Anna S, Miller Aaron L   +3 more
doaj   +1 more source

Promoter-context as a determinant of glucocorticoid receptor-responsiveness to activation of p38 and JNK mitogen-activated protein (MAP) kinases

General physiology and biophysics, 2012
MAP kinases JNK and p38 play an important role in many immune and inflammatory processes, whereas glucocorticoids exert immunosuppressive and anti-inflammatory activities. We found previously that activation of p38 or JNK inhibits glucocorticoid receptor (GR)-mediated transcriptional activation of a mouse mammary tumor virus (MMTV) promoter-driven ...
Anton Kebis, Zoltan Szatmary
openaire   +4 more sources

Differential Response of Heat-Shock-Induced p38 MAPK and JNK Activity in PC12 Mutant and PC12 Parental Cells for Differentiation and Apoptosis [PDF]

, 2010
Among the 3 mitogen-activated protein kinases -- ERK, p38 MAPK and JNK -- JNK has been suggested to participate in apoptosis, whereas p38 MAPK is thought to be part of the differentiation response.
Hiragami, Fukumi, Inoue, Shigeki, Kano, Yoshio, Kawamura, Kenji, Koike, Yoshihisa, Kumagishi, Kanae, Motoda, Hirotoshi, Murai, Hiroyasu, Ohtsuka, Aiji   +8 more
core   +1 more source