Results 151 to 160 of about 161,447 (312)

The Roles of c-Jun N-terminal Kinase (JNK) and p38 Mitogen-activated Protein Kinase (p38 MAPK) in Aged Pig Oocytes

Journal of Reproduction and Development, 2009
After reaching metaphase II, in vitro matured oocytes undergo the complex processes referred to as oocyte aging. Under our culture conditions, some aged oocytes remained at the stage of metaphase II, some underwent spontaneous parthenogenetic activation and others underwent cellular death, either through apoptosis (fragmentation) or lysis.
Ivana, Petrová, Markéta, Sedmíková, Jaroslav, Petr, Zuzana, Vodková, Petr, Pytloun, Eva, Chmelíková, Dalibor, Rehák, Andrea, Ctrnáctá, Radko, Rajmon, Frantisek, Jílek   +9 more
openaire   +3 more sources

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

Comparison of MAP kinases in the proliferation of chick utricular epithelial cells [PDF]

, 2010
Levels of activation of MAP kinase pathways and effects of inhibiting these pathways were examined in chick utricular epithelial cultures in order to determine the role of these pathways in ...
Spriggs, Meghan Kathleen
core   +1 more source

Ligand‐specific tuning of CLEC10A signalling strength and dendritic cell responses through engagement of different GalNAc‐containing glycan structures

The FEBS Journal, EarlyView.
The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs, Remi Hatinguais, Mike de Kok, R. J. Eveline Li, Tesfay M. Godefa, Victor L. J. L. Thijssen, Yvette van Kooyk, Sandra J. van Vliet   +7 more
wiley   +1 more source

Transient anoxia and oxyradicals induce a region-specific activation of MAPKs in the embryonic heart [PDF]

, 2018
We have previously reported in the early septating embryonic heart that electromechanical disturbances induced by anoxia-reoxygenation are distinct in atria, ventricle, and outflow tract, and are attenuated in ventricle by opening of mitochondrial KATP ...
Gardier, Stephany, Pedretti, Sarah, Raddatz, Eric, Sarre, Alexandre   +3 more
core  

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

EFFECT OF SOMAN ON JNK AND P38 MITOGEN ACTIVATED PROTEIN KINASE (MAPK) PATHWAYS [PDF]

Military Medical Science Letters, 2012
Jaroslav Pejchal, Jan Österreicher, Jiří Kassa, Václav Mařák, Aleš Tichý, Zuzana Šinkorová, Lenka Zárybnická, Klára Kubelková, Kamil Kuča   +8 more
openaire   +1 more source

Sacubitril/Valsartan Attenuates Inflammation and Fibrosis Associated With Decreased Integrin α8 and Inhibits Hepatocarcinogenesis in a Rat Model of Metabolic Dysfunction‐Associated Steatohepatitis

Hepatology Research, EarlyView.
Sacubitril/Valsartan (Sac/Val) alleviates fibrosis and inflammation in metabolic dysfunction‐associated steatohepatitis (MASH). Its anti‐fibrotic effect is linked to the suppression of Integrin alpha 8 (Itga8), a protein crucial for hepatic stellate cell (HSC) activation and collagen production.
Hayato Kawamura, Aya Naiki‐Ito, Xiaochen Kuang, Akihiro Murakami, Masayuki Komura, Takanori Suzuki, Hiroyuki Kato, Yuko Nagayasu, Kentaro Matsuura, Kei Fujiwara, Hiromi Kataoka, Satoru Takahashi   +11 more
wiley   +1 more source

Melatonin and the Dental Pulp: A Scoping Review

International Endodontic Journal, EarlyView.
ABSTRACT Background In general medicine, melatonin is known to enhance wound healing and promote stem cell differentiation. Its potential relevance in endodontics, however, remains underexplored. Objectives This scoping review aimed to systematically assess the available evidence on the effects of melatonin (a) on dental pulp tissue and (b) on human ...
Jasmin Schäfer, Konrad Kleszczynski, Edgar Schäfer   +2 more
wiley   +1 more source

Involvement of mitogen-activated protein kinases in mast cell mediator induced airway hyper-responsiveness in guinea pig trachea [PDF]

, 2016
Introduction: Exposure to allergens causes activation of mast cells and release of its mediators leading to airway constriction. Airway hyper-responsiveness (AHR) is a major characteristic of asthma but understanding of its causes is incomplete. Theories
Belikova, Maria
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