Results 71 to 80 of about 1,125,930 (294)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Does Order Negotiation Improve The Job-Shop Workload Control? [PDF]

open access: yes
Work flows in a job-shop are determined not only by the release load and the time between release factors, but also by the number of accepted orders.
M. Rosário Moreira, Rui Alves
core  

A Predictive-reactive Approach for JSP with Uncertain Processing Times [PDF]

open access: yes, 2010
The paper is supported by the Asia-Link project funded by the European Commission (CN/ASIA-LINK/024 (109093)), the National Natural Science Foundation of China (50705076, 50705077), and the National Hi-Tech R&D Program of China (2007AA04Z187)JSP with ...
NIU, Ganggang   +3 more
core  

A Dynamic Adjusted Aggregate Load Method to Support Workload Control Policies

open access: yesApplied Sciences, 2020
Workload control mechanisms are widely studied in the literature for the control of job-shop systems. The control of these systems involves acceptance, order release and priority dispatching.
Paolo Renna
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Better approximation guarantees for job-shop scheduling [PDF]

open access: yes
Job-shop scheduling is a classical NP-hard problem. Shmoys, Stein and Wein presented the first polynomial-time approximation algorithm for this problem that has a good (polylogarithmic) approximation guarantee.
Paterson, Michael S.   +3 more
core  

Um modelo para o planejamento e a programação da produção em ambientes job shop baseado em redes de Petri [PDF]

open access: yes, 2001
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de ProduçãoUm dos maiores desafios enfrentados pela administração da produção e do qual depende muito a eficiência de todo sistema ...
Chile Palomino, Reynaldo
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

PENYELESAIAN MASALAH JOB SHOP MENGGUNAKAN ALGORITMA GENETIKA

open access: yesJurnal Masyarakat Informatika, 2010
Job Shop Scheduling Problem (JSP) is a problem of work scheduling that can be describe by one or several job that have to be done by one or several source, each job contain of several operation that has to be done without interuption in several time and ...
Satriyo Adhy, Kushartantya Kushartantya
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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