Results 81 to 90 of about 1,125,930 (294)
, 2022 De JOB-monitor is in 2001 door Jongeren Organisatie Beroepsonderwijs (JOB) opgezet om de tevredenheid van mbo-studenten te meten. Elke twee jaar laat JOB de monitor uitvoeren door onderzoeksbureau ResearchNed.
ResearchNed
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Journal of Applied Mathematics, 2012 Scheduled production system leads to avoiding stock accumulations, losses reduction, decreasing or even eliminating idol machines, and effort to better benefitting from machines for on time responding customer orders and supplying requested materials in ...
Behnam Barzegar +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Proportionate Flow Shop Games [PDF]
In a proportionate flow shop problem several jobs have to be processed through a fixed sequence of machines and the processing time of each job is equal on all machines.By identifying jobs with agents, whose costs linearly depend on the completion time ...
Borm, P.E.M. +3 more
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Analysis of usage of genetic and tabu search algorithms in shop scheduling
Lietuvos Matematikos Rinkinys, 2008 A wide area of scheduling problem is industrial so-called shop scheduling (Job Shop, Flow Shop and Open Shop) which has important applications in real world industrial problems.
Edgaras Šakurovas +1 more
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Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Optimised search heuristic combining valid inequalities and tabu search [PDF]
This paper presents an Optimised Search Heuristic that combines a tabu search method with the verification of violated valid inequalities. The solution delivered by the tabu search is partially destroyed by a randomised greedy procedure, and then the ...
Helena Ramalhinho-Lourenço +1 more
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