Results 81 to 90 of about 41,258 (298)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
A hybrid job-shop scheduling system [PDF]
The intention of the scheduling system developed at the Fraunhofer-Institute for Material Flow and Logistics is the support of a scheduler working in a job-shop.
Bayat-Sarmadi, Fahid +3 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
job shop scheduling problem:literature review
Tikrit Journal of Pure Science, 2020 As an extension of the Job Shop Scheduling (JSP), Flexible job-shop Scheduling Problem (FJSP), can be defined as one of the most significant problems in up-to-date manufacturing systems, recently a lot of studies have been conducted to address FJSP ...
Marrwa Abd-AlKareem Alabajee +2 more
doaj +1 more source
Scheduling of job shop, make-to-order industries with recirculation and assembly: discrete versus continuous time models [PDF]
, 2009 This work studies the performance of two Mixed Integer Linear Programming (MILP) models to solve scheduling problems in a flexible job shop environment with recirculation and assembly using a due-date-based objective function. The models convey different
Barbosa-Póvoa, Ana Paula +2 more
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
A hybrid algorithm for flexible job-shop scheduling problem with setup times
International Journal of Production Management and Engineering, 2017 Job-shop scheduling problem is one of the most important fields in manufacturing optimization where a set of n jobs must be processed on a set of m specified machines.
Ameni Azzouz +2 more
doaj +1 more source
Optimised search heuristic combining valid inequalities and tabu search [PDF]
This paper presents an Optimised Search Heuristic that combines a tabu search method with the verification of violated valid inequalities. The solution delivered by the tabu search is partially destroyed by a randomised greedy procedure, and then the ...
Helena Ramalhinho-Lourenço +1 more
core
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Tabu search algorithms for job-shop problems with a single transport robot [PDF]
, 2001 We consider a generalized job-shop problem where the jobs additionally have to be transported between the machines by a single transport robot. Besides transportation times for the jobs, empty moving times for the robot are taken into account.
Hurink, J.L., Knust, S.
core +3 more sources