Results 41 to 50 of about 725,265 (297)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Il lavoro come atto linguistico e la fine dell’etica convenzionale del lavoro [PDF]
S&F_scienzaefilosofia.it, 2019 Job as a speech act and the end of conventional work Ethics According to the author, the work that takes place in the Cyber Physical System (Smart Factory) has the nature of the «performative speech act».
MARI, GIOVANNI
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La formation en animation socioculturelle en Suisse
Revue Internationale Animation, Territoires et Pratiques Socioculturelles, 2013 Cet article présente et analyse la réalité de la formation en animation socioculturelle en Suisse. Il aborde en premier lieu sa genèse et son évolution pour ensuite réaliser un état des lieux de la situation actuelle de la formation ainsi qu’un détour ...
Yuri Tironi +3 more
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EFFECT OF LONELINESS IN THE WORKPLACE ON EMPLOYEES’ JOB PERFORMANCE: A STUDY FOR HOSPITAL EMPLOYEES
International Journal of Health Services Research and Policy, 2019 Loneliness has become one of the most important problems of our time. Loneliness can be seen not only in daily life but also in the workplaces. Loneliness in the workplace has many negative effects on both employees and organizations.
Serkan DENİZ
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Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Scandinavian Journal of Work, Environment & Health, 2011 OBJECTIVES: High levels of work-related stress are associated with increased absenteeism from work and reduced work ability. In this study, we investigated the effects of a stress management intervention on absenteeism and return to work.
Morten Vejs Willert +2 more
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Women of Easy Living? Time, pleasure and suffering in the work of prostitutes [PDF]
RAE: Revista de Administração de Empresas, 2020 This study aims to analyze how temporal perceptions influence pleasure and suffering in the work of prostitutes in Belo Horizonte (MG). A descriptive and qualitative case study was carried out.
Kely César Martins de Paiva +4 more
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