Results 41 to 50 of about 158,216 (309)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

ANALYSIS OF THE EFFECT OF E-RECRUITMENT, EMPLOYER BRANDING, AND CORPORATE REPUTATION ON THE INTEREST OF GENERATION Z IN APPLYING FOR JOBS

Journal of Management Small and Medium Enterprises (SME's)
This study investigates the influence of e-recruitment, employer branding, and corporate reputation on job application interest among Generation Z fresh graduates in Surakarta City, Central Java.
Elisabet Putri Permatasari, Riska Fii Ahsani   +1 more
doaj   +1 more source

Jobless and Burnt Out: Digital Inequality and Online Access to the Labor Market

Social Inclusion, 2023
This article examines how inequalities in digital skills shape the outcomes of online job‐seeking processes. Building on a representative survey of Spanish job seekers, we show that people with high digital skill levels have a greater probability of ...
Stefano De Marco, Guillaume Dumont, Ellen Johanna Helsper, Alejandro Díaz-Guerra, Mirko Antino, Alfredo Rodríguez-Muñoz, José-Luis Martínez-Cantos   +6 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Why might AI-enabled interviews reduce candidates’ job application intention? The role of procedural justice and organizational attractiveness

Humanities & Social Sciences Communications
Despite substantial scientific developments, companies and professionals are unaware of or do not appreciate the negative repercussions linked to AI-enabled interviews.
Wenhao Luo, Yuelin Zhang, Maona Mu
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Nonstandard Work and the Job Search Process: Application Pools, Search Methods, and Perceived Job Quality

RSF: The Russell Sage Foundation Journal of the Social Sciences, 2019
Millions of workers labor in nonstandard employment relationships, such as part-time and temporary jobs. Yet little is known about how the job search process is influenced by such positions.
David S. Pedulla, Katariina Mueller-Gastell   +1 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source