Investigating transcription factor dynamics in health and disease using FRAP
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Real Wage Cyclicality of Job Stayers, within-Company Job Movers, and Between-Company Job Movers [PDF]
Using the British New Earnings Survey Panel Data for 1975–2001, the authors estimate the wage cyclicality (the degree to which wage levels rise and fall with economic upturns and downturns) of three groups: job stayers, within-company job movers, and ...
Hart, Robert A +5 more
core
Organisational Commitment in Malaysian Public Sector
This paper describes a research project that aims to determine the level of civil servants’ organisational commitment and the factors associated with it.
Sharifah Noraida Syed Zainal Abidin +3 more
doaj
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Effect of Job Size Characteristics on Job Scheduling Performance [PDF]
A workload characteristic on a parallel computer depends on an administration policy or a user community for the computer system. An administrator of a parallel computer system needs to select an appropriate scheduling algorithm that schedules multiple jobs on the computer system efficiently.
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Non-tenure track faculty are a growing majority in American higher education, but research examining their work lives is limited. Moreover, the theoretical frameworks commonly used by scholars have been critiqued for reliance on ideologically charged ...
Molly Ott, Jesus Cisneros
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Factors Affecting the Work Alienation in Employees of East Azerbaijan Health Insurance Organization [PDF]
Background and Objectives : Work alienation is related with negative consequences on the employees and the organization's efficiency. Persons, who experience alienation, have problems with their family, society and even themselves.
Mansoor yousefi, Akbar Azizi Zeinalhajlu
doaj
Effect of Job Rotation Perception on Librarians' Intention to Stay in Public Libraries of Taiwan's Special Municipalities: Mediating Roles of Perceived Job Characteristics and Job Satisfaction [PDF]
This study conducted a questionnaire survey targeting librarians in municipal public libraries in Taiwan to examine their perception of job rotation. The aim was to identify the relationships among job rotation perception, job characteristics perception,
Tz-Ping Liao, Hao-Ren Ke
doaj +1 more source

