Results 41 to 50 of about 256,057 (263)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Risk of childhood asthma following prenatal exposure to negative life events and job stressors: A nationwide register-based study in Denmark

Scandinavian Journal of Work, Environment & Health, 2019
OBJECTIVES: This study aimed to examine the association between negative life events, job stressors (low job control or high psychosocial job demands) and offspring asthma phenotypes (early-onset transient, early-onset persistent and late-onset asthma ...
Xiaoqin Liu, Kathrine Pape Madsen, Camilla Sandal Sejbaek, Henrik A Kolstad, Jens Peter Ellekilde Bonde, Jørn Olsen, Karin Sørig Hougaard, Kirsten Skamstrup Hansen, Niklas Worm Andersson, Reiner Rugulies, Vivi Schlünssen   +10 more
doaj   +1 more source

Is the association between poor job control and common mental disorder explained by general perceptions of control? Findings from an Australian longitudinal cohort

Scandinavian Journal of Work, Environment & Health, 2020
OBJECTIVES: This study sought to examine the influence of general perceptions of control on the association between job control and mental health. METHODS: We used four waves of data from a cohort of mid-aged adults from the Personality and Total Health (
Lay San Too, Liana Leach, Peter Butterworth   +2 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Do work factors modify the association between chronic health problems and sickness absence among older employees?

Scandinavian Journal of Work, Environment & Health, 2013
OBJECTIVES: The aim of this study was to (i) assess how common chronic health problems and work-related factors predict sickness absence and (ii) explore whether work-related factors modify the effects of health problems on sickness absence.
Fenna RM Leijten, Swenne G van den Heuvel, Jan Fekke Ybema, Suzan JW Robroek, Alex Burdorf   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Excuse me, but did the IPD-work consortium just “falsify” the job-strain model?

Scandinavian Journal of Work, Environment & Health, 2015
In a recent commentary (1) on a large (N=197 473) individual participant meta-analysis of job strain and incident coronary heart disease (CHD) (2), it was suggested that the population attributable risk (PAR) was smaller than expected (3.4%).
Michael Ingre
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Psychosocial Working Environment, Submarine Deployment, and Sleep among Navy Submarine Crews: An 8-day Longitudinal Study

Journal of Medical Sciences
Background: Employed as navy submariners is extremely demanding, especially during submarine deployments. The confined spaces and rotating shifts that deviate from a conventional 24-h cycle may disrupt submariners’ sleep–wake cycles, potentially ...
Ting-Ti Lin, Chia-Chen Yang, Pei-Chi Chan, Yu-Lun Tsai, Sheng-Huei Wang, Yu-Ju Chen   +5 more
doaj   +1 more source