Results 61 to 70 of about 1,501,822 (297)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Roles and responsibilities of open innovation specialists based on analysis of job advertisements

Journal of Innovation Management, 2018
Innovative companies are increasingly creating new open innovation functions and employing open innovation specialists to facilitate innovation processes. However, research that explores these emerging jobs remains scarce.
Justyna Dabrowska, Daria Podmetina
doaj   +1 more source

Pengaruh Analisis Jabatan Terhadap Pencapaian Kinerja Organisasi Di Universitas Muhammadiyah Surakarta [PDF]

, 2016
Penelitian ini dilakukan di Universitas Muhammadiyah Surakarta, yang bertujuan untuk mengetahui pengaruh analisis jabatan terhadap pencapaian kinerja organisasi baik secara langsung maupun tidak langsung.
, M. Farid Wajdi, MM, Ph.D, Giyarto, Giyarto   +1 more
core  

Identifying customer expectations is key to evidence based service delivery [PDF]

, 2010
As librarians and information professionals we share a common rationale: to deliver enhanced services for our customers. The importance of this is self-evident - if we don’t have customers we don't have a job. We therefore put our services at peril if we
Booth, A, McKnight, S
core   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Basics Fashion Design 08: Styling [PDF]

, 2011
Basics Fashion Design 08: Styling is the first comprehensive illustrated text book on fashion styling. The publication covers: a brief history of the origins of fashion styling, key stylists past and present, aspects of the job, essential research, a ...
Buckley, Clare, McAssey, Jacqueline
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

ANALYSIS AND PROJECTION OF JOB OPENINGS AT S.C. COMPANIA DE TRANSPORT FEROVIAR S.A. (COMPANY FOR RAILWAY TRANSPORT) BUCHAREST [PDF]

The whole process of getting a job refers to a set of measures, from the identification of the opportunity to offer a new job to the consolidation of the relationship with the new employee starting the first day after accepting the job.
Cirlanescu Zota Maria, Popescu Catalin
core  

BaBar simulation production - A millennium of work in under a year [PDF]

, 2006
The BaBar experiment requires simulated events beyond the ability of a single computing site to provide. This paper describes the evolution of simulation and job management methods to meet the physics community requirements and how production became ...
Blanc, F, Bozzi, C, Khan, A, Smith, D A
core   +1 more source