Results 81 to 90 of about 46,513 (296)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Demographic Differences in Job Satisfaction and Work Engagement in a South African Government Department

open access: yesInternational Journal of Applied Research in Business and Management
Employee job satisfaction (JS) and work engagement (WE) have become critical factors in the South African (SA) government. The primary purpose of this study was to determine if there are any statistically significant differences between demographic ...
Mahlako Mashu Mothema   +2 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Tenure Profiles and Efficient Separation in a Stochastic Productivity Model [PDF]

open access: yes
This paper provides a new way of analyzing tenure profiles in wages, by modelling simultaneously the evolution of wages and the distribution of tenures.
Sebastian Buhai, Coenraad N. Teulings
core  

Absenteeism among public health nurses : does commitment matter? [PDF]

open access: yes, 2006
Includes bibliographical references (leaves 69-73)This study explored the relationship between absenteeism and commitment (affective, continuance and normative commitment) as directed towards the organisation, co-workers and the nursing profession.
Ramsay, Nadine
core  

Job and off‐job crafting profiles: Time‐lagged relationships with job, home and personal resources and well‐being outcomes

open access: yesJournal of Occupational and Organizational Psychology
Abstract Crafting research has often focused solely on the work domain or examined work and non‐work life domains separately, using a variable‐centered approach. Little is known about the interactions of crafting processes in the work and non‐work domain.
Ho, Kang Leng   +5 more
openaire   +5 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Middle-Age Job Mobility: Its Determinants and Consequences [PDF]

open access: yes
Our paper uses the wealth of information available in the NLS to expand on previous work in several ways. First, we investigate whether there is a meaningful distinction among types of job separations. Traditional analysis has categorized job separations
Ann P. Bartel, George J. Borjas
core  

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