Results 71 to 80 of about 1,901,812 (345)

Scheduling of non-repetitive lean manufacturing systems under uncertainty using intelligent agent simulation [PDF]

, 2008
World-class manufacturing paradigms emerge from specific types of manufacturing systems with which they remain associated until they are obsolete. Since its introduction the lean paradigm is almost exclusively implemented in repetitive manufacturing ...
Mousavi, A, Papadopoulou, T C
core   +1 more source

Job shop control:in search of the key to delivery improvements [PDF]

, 2015
The last major performance breakthroughs in job shop control stem from the 1980s and 1990s. We generate a new search direction for designing job shop control policies, providing a key to delivery improvements.
Gaalman, Gerard J. C., Land, Martin, Stevenson, Mark, Thurer, Matthias   +3 more
core   +2 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Flexible job-shop scheduling problem with parallel batch machines based on an enhanced multi-population genetic algorithm

Complex & Intelligent Systems
The flexible job-shop scheduling problem (FJSP) with parallel batch processing machine (PBM) is one of those long-standing issues that needs cutting-edge approaches. It is a recent extension of standard flexible job shop scheduling problems.
Lirui Xue, Shinan Zhao, Amin Mahmoudi, Mohammad Reza Feylizadeh   +3 more
doaj   +1 more source

Models and Strategies for Variants of the Job Shop Scheduling Problem [PDF]

, 2011
Recently, a variety of constraint programming and Boolean satisfiability approaches to scheduling problems have been introduced. They have in common the use of relatively simple propagation mechanisms and an adaptive way to focus on the most constrained ...
A. Caumond, A. Mascis, A. Schutt, C. Artigues, C. Rajendran, C.J. Schuster, D. Grimes, D. Grimes, D.A. Wismer, J.C. Beck, J.C. Beck, N. Tamura, P. Baptiste, T. Feydy, T.E. Morton, W. Bozejko   +15 more
core   +3 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Tabu search algorithms for job-shop problems with a single transport robot [PDF]

, 2001
We consider a generalized job-shop problem where the jobs additionally have to be transported between the machines by a single transport robot. Besides transportation times for the jobs, empty moving times for the robot are taken into account.
Hurink, J.L., Knust, S.
core   +3 more sources

Capacity Planning and Leadtime management [PDF]

, 1996
In this paper we discuss a framework for capacity planning and lead time management in manufacturing companies, with an emphasis on the machine shop. First we show how queueing models can be used to find approximations of the mean and the variance of ...
Buitenhek, R., Zijm, W.H.M.
core   +2 more sources

Bi-local search based variable neighborhood search for job-shop scheduling problem with transport constraints

Optimization Letters, 2020
In job-shop manufacturing systems, an efficient production schedule acts to reduce unnecessary costs and better manage resources. For the same purposes, modern manufacturing cells, in compliance with industry 4.0 concepts, use material handling systems ...
Moussa Abderrahim, A. Bekrar, D. Trentesaux, N. Aissani, K. Bouamrane   +4 more
semanticscholar   +1 more source