Results 71 to 80 of about 737,186 (350)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Models and Strategies for Variants of the Job Shop Scheduling Problem [PDF]

, 2011
Recently, a variety of constraint programming and Boolean satisfiability approaches to scheduling problems have been introduced. They have in common the use of relatively simple propagation mechanisms and an adaptive way to focus on the most constrained ...
A. Caumond, A. Mascis, A. Schutt, C. Artigues, C. Rajendran, C.J. Schuster, D. Grimes, D. Grimes, D.A. Wismer, J.C. Beck, J.C. Beck, N. Tamura, P. Baptiste, T. Feydy, T.E. Morton, W. Bozejko   +15 more
core   +4 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Does Order Negotiation Improve The Job-Shop Workload Control? [PDF]

Work flows in a job-shop are determined not only by the release load and the time between release factors, but also by the number of accepted orders.
M. Rosário Moreira, Rui Alves
core  

PENGARUH KOMPENSASI DAN KEPUASAN KERJA TERHADAP TURNOVER INTENTION PADA KARYAWAN COFFEE SHOP (Studi pada karyawan Coffee shop di Kota Malang) [PDF]

, 2023
The purpose of this study is to determine turnover intention, compensation, and job satisfaction, the effect of compensation on turnover intention, the effect of job satisfaction on turnover intention, the effect of compensation and job satisfaction ...
Fharisa, M. Dhitya
core  

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

A bilevel programming approach to assembly job shop scheduling [PDF]

, 2009
A bilevel programming approach for assembly job shop scheduling isproposed. Two levels of decision makers are identified in the model. The firstlevel is the project manager and the second level is the shop floor manager.
Huang, GQ, Lu, H
core   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

PEMAKAIAN ALGORITMA GENETIK UNTUK PENJADWALAN JOB SHOP DINAMIS NON DETERMINISTIK

Jurnal Teknik Industri, 2004
Dynamic Job shops non deterministic scheduling problem is concerned with ordering some operations that processed by certain machines with variable and unknown arrival time of jobs. When new jobs arrive, it requires modifications in the existing schedule.
Nico Saputro, Yento Yento
doaj