Results 31 to 40 of about 67,577 (216)
Economic resources and the first child in Italy: A focus on income and job stability
Demographic Research, 2011 At the turn of the twentieth century Italy registered a lowest-low fertility level, i.e., a total fertility rate of 1.26 children per woman in 2000. In this paper we investigate whether and how in that period economic resources and, in particular, income
Elisabetta Santarelli
doaj
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
A Preliminary Study of the Relationship between Personality Traits and Job Stress in Chinese General Practitioners: a Survey Based on the Job Demands and Resources Model [PDF]
Zhongguo quanke yixueObjective Job demands and job resources are drivers of health and wellbeing of workfoce. This study aimed to explore the influence of personality traits on job stress in the Job Demands and Resources (JD-R) model.
HUANG Wenjing, QIU Shanjiao, LIANG Yanchang, ZHENG Sihua, ZHAN Licheng, CHEN Miaoyuan, ZENG Yue, LYU Yun, YANG Hui
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Single Machine Scheduling Problem with Interval Processing Times and Total Completion Time Objective
Algorithms, 2018 We consider a single machine scheduling problem with uncertain durations of the given jobs. The objective function is minimizing the sum of the job completion times.
Yuri N. Sotskov, Natalja G. Egorova
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
RAM. Revista de Administração Mackenzie, 2018 Purpose: The objective of this research is to analyze the job satisfaction of public servants through career anchors. Originality/value: The contribution of this research is to apply a collection instrument in reduced version for the analysis of job ...
Rosângela C. Vargas +1 more
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Factors affecting the work competency and stability of family doctors in Shanghai: a tracking study
BMC Family Practice, 2019 Background Family doctors can fulfill the gatekeeper duty to protect the residents’ health, which depends on their work competency and stability. The study aimed to identify factors influencing work competency and stability among Shanghai family doctors.
Shanshan Liu +6 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source