Results 61 to 70 of about 852,963 (281)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Conjectures About Wheels Without One Edge with Paths and Cycles

Mathematics
The crossing number cr(G) of a graph G is the minimum number of edge crossings over all drawings of G in the plane. The main aim of this paper is to give the crossing numbers of the join products G*+Pn and G*+Cn for the connected graph G* obtained by ...
Michal Staš, Mária Timková
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Product version of reciprocal degree distance of composite graphs

Communications in Combinatorics and Optimization, 2018
In this paper‎, ‎we present the upper bounds for the product version of reciprocal degree distance of the tensor product‎, ‎join and strong product of two graphs in terms of other graph invariants including the Harary index and Zagreb indices‎.
K‎. ‎Pattabiraman
doaj   +1 more source

Szeged-type indices of subdivision vertex-edge join (SVE-join)

Main Group Metal Chemistry, 2021
In this article, we compute the vertex Padmakar-Ivan (PIv) index, vertex Szeged (Szv) index, edge Padmakar-Ivan (PIe) index, edge Szeged (Sze) index, weighted vertex Padmakar-Ivan (wPIv) index, and weighted vertex Szeged (wSzv) index of a graph product ...
Asghar Syed Sheraz, Binyamin Muhammad Ahsan, Chu Yu-Ming, Akhtar Shehnaz, Malik Mehar Ali   +4 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Strong incidence domination in some operations of fuzzy incidence graphs and application in security allocation

International Journal of Mathematics for Industry
This paper explores operations on fuzzy incidence graphs (FIGs), focusing on join, Cartesian product, tensor product, and composition. Emphasizing strong fuzzy incidence graphs (SFIGs), the study examines strong incidence domination (SID) and the strong ...
Kavya R. Nair, M. S. Sunitha
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Operations on Intuitionistic Fuzzy Graph Structures

Fuzzy Information and Engineering, 2016
An intuitionistic fuzzy graph structure (IFGS) is a generalization of an intuitionistic fuzzy graph. The concept of intuitionistic fuzzy graph structure is introduced and investigated in this paper.
Muhammad Akram, Rabia Akmal
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source