Results 71 to 80 of about 858,413 (284)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Operations on Intuitionistic Fuzzy Graph Structures
Fuzzy Information and Engineering, 2016 An intuitionistic fuzzy graph structure (IFGS) is a generalization of an intuitionistic fuzzy graph. The concept of intuitionistic fuzzy graph structure is introduced and investigated in this paper.
Muhammad Akram, Rabia Akmal
doaj +1 more source
Fool’s solitaire on joins and Cartesian products of graphs
Discrete Mathematics, 2015 Peg solitaire is a game generalized to connected graphs by Beeler and Hoilman. In the game pegs are placed on all but one vertex. If $xyz$ form a 3-vertex path and $x$ and $y$ each have a peg but $z$ does not, then we can remove the pegs at $x$ and $y$ and place a peg at $z$. By analogy with the moves in the original game, this is called a jump.
Loeb, Sarah, Wise, Jennifer
openaire +3 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
The G-Convexity and the G-Centroids of Composite Graphs
Mathematics, 2020 The graph centroids defined through a topological property of a graph called g-convexity found its application in various fields. They have classified under the “facility location” problem.
Prakash Veeraraghavan
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
European - North American - Russian Federation Inland ENC Harmonization Group [PDF]
, 2007 In 2003, the Inland ENC Harmonization Group (IEHG) was formed to agree upon specifications for Inland ENCs that are suitable for all known Inland ENC data requirements for safe and efficient navigation in European and North American inland waterways and ...
Alexander, Lee +4 more
core +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Entry and access : how shareability comes about [PDF]
, 2007 Shareability is a design principle that refers to how a system, interface, or device engages a group of collocated, co-present users in shared interactions around the same content (or the same object).
Hornecker, E., Marshall, P., Rogers, Y.
core