Results 51 to 60 of about 95,004 (291)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
Research on Influence of Joint Clearance on Precision of 3-TPT Parallel Robot [PDF]
Mechanical Sciences, 2019 The error model of the working accuracy of parallel mechanism was established in this paper. The D-H matrix method and error independent method were used to analyze the clearance error of mechanism joint based on the inverse position kinematics solution.
C. Zhu, Z. Zhao
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Shear joint capability versus bolt clearance [PDF]
, 1992 The results of a conservative analysis approach into the determination of shear joint strength capability for typical space-flight hardware as a function of the bolt-hole clearance specified in the design are presented. These joints are comprised of high-
Lee, H. M.
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Dynamics Model of 4-SPS/CU Parallel Mechanism With Spherical Clearance Joint and Flexible Moving Platform [PDF]
, 2017 Effects of flexible body and clearance spherical joint on the dynamic performance of 4-SPS/CU parallel mechanism are analyzed. The flexible moving platform is treated as thin plate based on absolute nodal coordinate formulation (ANCF).
Hongzhao Liu, Gengxiang Wang
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Nonlinear Characteristic of Spherical Joints with Clearance
Journal of Aerospace Technology and Management, 2015 Joints in deployable structures can degrade the stiffness and the stability of spacecraft. In this study, the nonlinear stiffness of spherical joints is investigated. The traditional contact model of spherical joints based on non-conforming contact assumption is presented.
Jing, Zhang +3 more
openaire +5 more sources