Results 61 to 70 of about 92,462 (263)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Effect of joint clearance on fatigue strength of brazed joint.
QUARTERLY JOURNAL OF THE JAPAN WELDING SOCIETY, 1989 The effects of joint clearance on fatigue crack initiation life and crack growth rate of brazed joint were investigated.Tes tspecimens used were butt joint of carbon stcel and stainless steel brazed with pure copper with/without an artificial defect in joint.It was inferred from the fatigue test results that fatigue life of joint depend not on crack ...
openaire +2 more sources
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Dynamics Simulation and Experiment of the Slider-crank Mechanism with Dry Friction Clearance Joint
Jixie chuandong, 2017 Based on dynamics simulation software,the dynamics analysis of the slider-crank mechanism with clearance joint is carried out and the effect of joint with different clearance size under dry contact and non-friction conditions on dynamic response of ...
Han Yuncheng, Xu Lixin, Huang Xiaoqiu
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International Journal of Mechanical System Dynamics, 2021 Due to assembly, wear and manufacturing errors and clearance in the joints are inevitable. When the clearance is introduced into a mechanical system, the impact force in the clearance joint will cause undesirable vibration of the system.
Zhengfeng Bai, Fusong Xu, Jijun Zhao
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Jixie chuandong, 2001 This paper takes account of the boundary condition of elements of a joint with clearance when contact occur, by using the nonlinear spring damper formulation to model the resulting reaction force between the elements of clearance joint.
王国庆, 刘宏昭
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