Results 81 to 90 of about 309,051 (306)

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

A Study on the strength of the Bolted Joint & Pin Joint with Hole Clearance

Journal of The Korean Society for Composite Materials, 2012
With the wide application of fiber-reinforced composite material in aero-structures and mechanical parts, composite joint have become a very important research area because they are often the weakest sites in composite structures. In this paper, the failure strengths of the bolted joint and pin joint which have variable hole clearance were evaluated ...
Kang-Woo Jeong, Jin-Ho Choi, Jin-Hwe Kweon   +2 more
openaire   +2 more sources

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang, Chengsong Yue, Zhuang Li, Xiaolei Shi, Haoxuan Zhu, Jie Yang, Linyu Li, Jiaxing Song, Shitao Fan, Gaoming Li, Wenzhe Sun, Zhixian Ye, Jiacheng Huang, Dahong Yang, Jinfu Ma, Xu Xu, Zhixi Wang, Lilan Wang, Guojian Liu, Fengli Li, Changwei Guo, Li Qi, Wenjie Zi   +22 more
wiley   +1 more source

3D Revolute Joint with Clearance in Multibody Systems [PDF]

, 2017
The aim of this paper is to understand the influence of radial and axial clearance in the revolute joints on the overall performance of a circuit breaker. A circuit breaker mechanism is made of seven links, seven revolute joints with clearance in both radial and axial direction, four unilateral contacts with friction, and it has forty-two degrees of ...
Akhadkar, Narendra, Acary, Vincent, Brogliato, Bernard   +2 more
openaire   +1 more source

Shear joint capability versus bolt clearance [PDF]

The results of a conservative analysis approach into the determination of shear joint strength capability for typical space-flight hardware as a function of the bolt-hole clearance specified in the design are presented. These joints are comprised of high-
Lee, H. M.
core   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Research on Non-Probabilistic Reliability Partitioning Methods for Large Workspace Robots

Machines
Large-scale high-end equipment robotic precision operations have large workspaces and numerous uncertainties. They have an unevenly distributed error effect on the position in space. The current conventional stereotyping method ignores the uncertainty in
Jianping Sun, Weian Yang, Xin Meng, Jun Peng, Zhaoping Tang   +4 more
doaj   +1 more source

Dynamic Analysis of the Mechanism with Joint Clearance [PDF]

, 2015
随着工业水平的不断发展，含间隙机构的动力学及其控制的研究逐渐成为了一个热门课题。由于间隙的存在对机械机构的动力学特性造成了一定的影响，所以分析运动副间隙的影响对于机械机构设计和优化的意义就显得十分重大。本文中主要是以具有代表性的含间隙曲柄滑块机构和机械手臂机构为例，来分析间隙以及柔性因素给机械机构动力学特性带来的一些影响。 建立了机械系统的动力学方程，为含间隙机构动力学分析研究提供了理论基础；分析了基于弹簧阻尼模型的Impact接触碰撞函数，为研究轴与轴套间的接触碰撞过程提供了理论依据 ...
牟佳冬
core  

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source