Results 71 to 80 of about 3,379,584 (355)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Performance of bolted steel-beam to CFST-column joints using stiffened angles in column-removal scenario [PDF]
, 2019 This paper presents three experimental investigations on the performance of steel-beam to CFST-column joints using stiffened angle, long bolts and fin plate under a middle column removal scenario. Three specimens were designed and tested.
Fu, F., Gao, S., Guo, L., Xu, M.
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Modelling of timber joints in traditional structures [PDF]
, 2006 Original unstrengthened timber connections and the effects of different strengthening techniques have been evaluated experimentally with tests on full-scale birdsmouth joints.
Branco, J. +3 more
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Rheological aging and rejuvenation in solid friction contacts
, 2002 We study the low-velocity (0.1--100 $\mu$m.s$^{-1}$) frictional properties of interfaces between a rough glassy polymers and smooth silanized glass, a configuration which gives direct access to the rheology of the adhesive joints in which shear localizes.
Baumberger, T., Bureau, L., Caroli, C.
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Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Spontaneous elbow hemarthrosis identified by point-of-care ultrasound [PDF]
Clinical and Experimental Emergency Medicine, 2017 Traumatic or spontaneous hemarthroses are an important cause of joint effusions, and can complicate innate or acquired coagulopathies. The elbow is an unusual location for a spontaneous hemarthrosis; we describe a previously unreported case of warfarin ...
David C. Mackenzie, Scott McCorvey
doaj +1 more source
Seismic strengthening of beam-column joints with multidirectional CFRP laminates [PDF]
, 2012 An experimental program was carried out to analyse the potentialities of a technique based on the use of multidirectional CFRP laminates (MDL-CFRP) for the seismic repair and strengthening of reinforced concrete (RC) beam-column joints. This experimental
Barros, J. +6 more
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Current opinion: where are we in our understanding and treatment of osteoarthritis?
Swiss Medical Weekly, 2016 There has been important recent progress in our understanding of the molecular pathology of osteoarthritis (OA) and how it might be treated. New technologies have been developed and others refined to identify patients for recruitment in clinical trials
Anthony Robin Poole
doaj +1 more source