Results 61 to 70 of about 571,983 (243)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Some properties of bolted joints [PDF]

The roles of surface roughness and of surface flatness in determining the properties of structural joints are discussed. A method of measuring the effects of errors of form on joint stiffness is given.
Heath, Thomas V.
core  

Design and analysis of DLS steel/composite thick-adhernd adhesive joints

, 2009
The paper describes experimental and numerical techniques to study the structural design and behaviourof thick-adherend DLS joints that are based on steel /steel and steel/composites and epoxy adhesives, withfocus on long overlap joints.
Tsouvalis, N, Chirica, I., Nisar, J., McGeorge, D, Hashim, S.A., Moore, P., Hashim, S., Chirca, I., Berggreen, C., Anyfantis, K, Berggreen, Christian, Moore, P, Juin, E., Boyd, S., McGeorge, D., Nisar, J, Hashim, S, Tsouvalis, N., Anyfantis, K., Misirlis, K., Chirica, I, Boyd, S.W., Juin, E, Misirlis, K, Anyfantis, Konstantinos N., Berggreen, C, Boyd, S   +26 more
core   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Prevalence and associated factors of multi-ethnic adolescent idiopathic scoliosis in Longlin, Southwestern China: a school-based cross-sectional study

Frontiers in Public Health
ObjectiveTo determine the prevalence of adolescent idiopathic scoliosis (AIS) and its associated factors among multi-ethnic schoolchildren in Southwestern China.MethodsA cross-sectional school-based study was conducted involving 22,814 students aged 10 ...
Chengxiang Hu, Baocheng Lin, Fengtao Li, Zhixing Li, Xiaozhuan Chen   +4 more
doaj   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Spinal 7-dehydrocholesterol reductase dependent cholesterol overload regulates astrocyte activation and mGluR5/ERK cascades via monocyte chemotactic protein 3 in tibial fracture-induced chronic pain in mice

Neuroscience Research
Patients with bone fractures commonly experience an exasperating and long-lasting pain following orthopedic procedures. Spinal monocyte chemotactic protein 3 (MCP-3)-encoding astrogliosis and mGluR5-mediated excitatory synaptic plasticity are essential ...
Chao Qi, Jian Zhao, Donghui Guo, Shiqiang Ma, Hengjun Wang, Xingyue Wang, Hao Zhou, Zhenhui Huo, Xiaoming Li, Xin Fu, Jun Liu   +10 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source