Results 61 to 70 of about 589,923 (295)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Videos in short-video sharing platforms as sources of information on osteoarthritis: cross-sectional content analysis study

Frontiers in Digital Health
BackgroundOsteoarthritis (OA) is a debilitating condition characterized by pain, stiffness, and impaired mobility, significantly affecting patients' quality of life. Health education is crucial in helping individuals understand OA and its management.
Yi-xiang Zhang, Yi-xiang Zhang, Hao-tian Yin, Hao-tian Yin, Ya-xing Liu, Ya-xing Liu, Xin Fu, Jun Liu, Jun Liu, Jun Liu   +9 more
doaj   +1 more source

Spontaneous elbow hemarthrosis identified by point-of-care ultrasound [PDF]

Clinical and Experimental Emergency Medicine, 2017
Traumatic or spontaneous hemarthroses are an important cause of joint effusions, and can complicate innate or acquired coagulopathies. The elbow is an unusual location for a spontaneous hemarthrosis; we describe a previously unreported case of warfarin ...
David C. Mackenzie, Scott McCorvey
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Current opinion: where are we in our understanding and treatment of osteoarthritis?

Swiss Medical Weekly, 2016
There has been important recent progress in our understanding of the molecular pathology of osteoarthritis (OA) and how it might be treated. New technologies have been developed and others refined to identify patients for recruitment in clinical trials
Anthony Robin Poole
doaj   +1 more source

Numerical study on shear strength of GFRP-RC T-Joints

, 2022
This paper presents the numerical modeling and behavior of glass fiber-reinforced polymer (GFRP) reinforced concrete (RC) exterior beam-column joints (T-joints) under cyclic loading.
Muhammad NS Hadi (19246408), Muhammad Safdar (1474231), M Neaz Sheikh (19188730)   +2 more
core   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Experimental analysis of damping across joints in metal plates

, 2006
In the current world of engineering, structural vibration problems continue impact the design and construction of a wide range of products. Amid the parameters that determine the dynamic behaviour of a structure the one that takes into account the ...
Cunningham, PR, Cunningham, Paul R., Walker, Scott, Aglietti, GS, Walker, SJI, Aglietti, Guglielmo S., Cunningham, P.R., Walker, Scott J.I., Aglietti, G.S.   +8 more
core   +1 more source