Results 71 to 80 of about 3,576,842 (407)

The Surgical Release of Dupuytren's Contracture Using Multiple Transverse Incisions. [PDF]

, 2012
Dupuytren's contracture is a condition commonly encountered by hand surgeons, although it is rare in the Asian population. Various surgical procedures for Dupuytren's contracture have been reported, and the outcomes vary according to the treatment ...
Cho, Sanghun, Eo, Surak, Jones, Neil F, Lee, Hyunjic   +3 more
core   +3 more sources

OP0195 TARGETED ABLATION OF KNEE-INNERVATING NOCICEPTORS HAS PROFOUND EFFECTS ON JOINT DAMAGE IN EXPERIMENTAL OSTEOARTHRITIS [PDF]

, 2023
Luwei Wang, S. Ishihara, J. LI, Alia M. Obeidat, Rachel E. Miller, Anne‐Marie Malfait   +5 more
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Glaucocalyxin A delays the progression of OA by inhibiting NF-κB and MAPK signaling pathways

Journal of Orthopaedic Surgery and Research
Background Osteoarthritis (OA) is a common degenerative joint condition marked by inflammation and cartilage breakdown. Currently, there is a dearth of treatment medications that can clearly slow the course of OA.
Xin Hong, Xuqiang Liu, Bo Li, Shoujie Shi, Kai Xiao, Tiantian Xu, Yaoyang Nie, Min Dai, Meisong Zhu   +8 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Modelling of timber joints in traditional structures [PDF]

, 2006
Original unstrengthened timber connections and the effects of different strengthening techniques have been evaluated experimentally with tests on full-scale birdsmouth joints.
Branco, J., Cruz, P., Piazza, M., Varum, H.   +3 more
core   +1 more source

Large joints in graphs

, 2010
We show that if G is a graph of sufficiently large order n containing as many r-cliques as the r-partite Turan graph of order n; then for some C>0 G has more than Cn^(r-1) (r+1)-cliques sharing a common edge unless G is isomorphic to the the r-partite ...
Bollobas, Bela, Nikiforov, Vladimir
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Videos in short-video sharing platforms as sources of information on osteoarthritis: cross-sectional content analysis study

Frontiers in Digital Health
BackgroundOsteoarthritis (OA) is a debilitating condition characterized by pain, stiffness, and impaired mobility, significantly affecting patients' quality of life. Health education is crucial in helping individuals understand OA and its management.
Yi-xiang Zhang, Yi-xiang Zhang, Hao-tian Yin, Hao-tian Yin, Ya-xing Liu, Ya-xing Liu, Xin Fu, Jun Liu, Jun Liu, Jun Liu   +9 more
doaj   +1 more source

Spontaneous elbow hemarthrosis identified by point-of-care ultrasound [PDF]

Clinical and Experimental Emergency Medicine, 2017
Traumatic or spontaneous hemarthroses are an important cause of joint effusions, and can complicate innate or acquired coagulopathies. The elbow is an unusual location for a spontaneous hemarthrosis; we describe a previously unreported case of warfarin ...
David C. Mackenzie, Scott McCorvey
doaj   +1 more source