Results 71 to 80 of about 500,766 (315)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Experimental studies of scale effects on shear strength, and deformation of rock joints [PDF]
, 1980 The effect of scale on shear strength is studied by performing direct shear tests on different sized samples of large joints. A rubber moulding system is used to obtain impressions of the roughness from a variety of natural joint surfaces.
Bandis, Stavros
core
A finite element modelling methodology for the non-linear stiffness evaluation of adhesively bonded single lap-joints. Part 2, Novel shell mesh to minimise analysis time [PDF]
, 2012 A new modelling methodology is presented that enables the stiffness of adhesively bonded single lap-joints to be included in the finite element analysis of whole vehicle bodies. This work was driven by the need to significantly reduce computing resources
Pearson, Ian T. +3 more
core +1 more source
Current opinion: where are we in our understanding and treatment of osteoarthritis?
Swiss Medical Weekly, 2016 There has been important recent progress in our understanding of the molecular pathology of osteoarthritis (OA) and how it might be treated. New technologies have been developed and others refined to identify patients for recruitment in clinical trials
Anthony Robin Poole
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Three dimensional geometrical and material nonlinear finite element analysis of adhesively bonded joints for marine structures [PDF]
, 2005 The use of adhesive bonding as a structural joining method has been gaining recognition in marine industry in recent years, though it has been widely adopted in other fields such as aerospace, automobiles, trains and in civil constructions.
Sampathkumar, Narasimhan
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Cyclic response of RC beam-column joints reinforced with plain bars: an experimental testing campaign [PDF]
, 2012 Existing reinforced concrete (RC) buildings constructed until the mid-70’s, with plain reinforcing bars, are expected to behave poorly when subjected to earthquake actions.
Costa, A. +3 more
core +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source