Results 41 to 50 of about 589,923 (295)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Effect of single-bundle autologous hamstring tendon reconstruction combined with braided thread on joint stability and clinical efficacy in patients with posterior cruciate ligament rupture

Archives of Medical Science
Introduction Single-bundle autologous hamstring tendon reconstruction is a surgical procedure used primarily in orthopedics. The aim of the study was to investigate the impact of using autologous hamstring tendon single-bundle restoration in conjunction ...
Wenqiao Zhang, Zhanzhen LI, Mianliang Zhang   +2 more
doaj   +1 more source

A case of knuckle pad syndrome in a middle‐aged man

Clinical Case Reports, 2022
Knuckle pads are benign papules, nodules, or plaques overlying joints and typically manifest at the proximal interphalangeal joints (PIPs). They may be confused with other dermatologic or rheumatologic diseases. Treatment options for primary knuckle pads
Zachary Chandler, Kimberly Seamon, Karishma Ramsubeik, Gurjit Kaeley   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Surgery and joint replacement for joint disease [PDF]

Acta Orthopaedica Scandinavica, 1998
(1998). Surgery and joint replacement for joint disease. Acta Orthopaedica Scandinavica: Vol. 69, The Bone and Joint Decade 2000–2010 for prevention of musculo-skeletal disorders: Lund, Sweden, April 17–18, 1998, pp. 17-20.
openaire   +3 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Research on the Electric Field Distribution and Structure Optimizing  of Integral Prefabricated Joint and Taped Joint

Journal of Harbin University of Science and Technology, 2018
Integral prefabricated joint and taped joint are two kinds of widely used cable joint.Because of the different structure and conductivity of insulation, there is great difference in the electric field distribution between the two kinds of joints .In this
CHEN Zhen-xin, YU En-ke, WANG Yang, ZHOU Ze-wei, DUAN Ran, QUE Shan-ting, LE Yan-jie, CHEN Guo-zhi   +7 more
doaj   +1 more source

Design and analysis of joints between light composite superstructure and steel hull

Zhongguo Jianchuan Yanjiu, 2020
[Objectives] Designing effective and reliable composite and steel joints is one of the difficulties faced in the application of composite superstructure in ships.[Methods] Considering the advantages and disadvantages of various joint structures,the π ...
LI Han, GUO Zhanyi
doaj   +1 more source

Seismic strengthening of beam-column joints with multidirectional CFRP laminates [PDF]

, 2012
An experimental program was carried out to analyse the potentialities of a technique based on the use of multidirectional CFRP laminates (MDL-CFRP) for the seismic repair and strengthening of reinforced concrete (RC) beam-column joints. This experimental
Costa, A., Barros, Joaquim A. O., Varum, Humberto, Barros, J., Varum, H., Sena-Cruz, José, Coelho, M., Fernandes, P., Sena-Cruz, J., Melo, José, Costa, Aníbal, Coelho, Mário Rui Freitas, Melo, J., Fernandes, Pedro Miguel Gomes   +13 more
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