Results 81 to 90 of about 3,379,584 (355)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Finite Element Analysis of Adhesively Bonded Lap Joints [PDF]
, 2006 Adhesive bonding is a preferred method of joining aerospace structural components, since it provides fewer points of stress concentration compared to fastener joints.
Dattaguru, B, Murthy, CRL, Sahoo, PK
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Frontiers in Public HealthObjectiveTo determine the prevalence of adolescent idiopathic scoliosis (AIS) and its associated factors among multi-ethnic schoolchildren in Southwestern China.MethodsA cross-sectional school-based study was conducted involving 22,814 students aged 10 ...
Chengxiang Hu +4 more
doaj +1 more source
Multi–scale modelling of timber–frame structures under seismic loads [PDF]
, 2013 This paper introduces a versatile hysteretic constitutive law, developed for various joints with steel fasteners commonly used in timber structures (nails, screws, staples, 3D connectors of bracket type, punched plates). Compared to previous
Baroth, Juliene +3 more
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Quantitative sensory testing in painful hand osteoarthritis demonstrates features of peripheral sensitisation. [PDF]
, 2012 Hand osteoarthritis (HOA) is a prevalent condition for which treatments are based on analgesia and physical therapies. Our primary objective was to evaluate pain perception in participants with HOA by assessing the characteristics of nodal involvement ...
Ejindu, V +5 more
core +2 more sources
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
Simplified procedures for designing composite bolted joints [PDF]
Simplified procedures are described to design and analyze single and multi-bolt composite joints. Numerical examples illustrate the use of these methods. Factors affecting composite bolted joints are summarized.
Chamis, Christos C.
core +1 more source
Spectrum of arthroscopic findings in 84 canine elbow joints diagnosed with medial compartment erosion [PDF]
, 2018 Elbow dysplasia is an important cause of forelimb lameness in large breed dogs. The aim of this study was to report on the arthroscopic findings associated with medial compartment erosion (MCE) of the canine elbow joint.
Broeckx, Bart +6 more
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